Steroid hormone withdrawal syndromes - Pathophysiology and clinical significance
Steroid hormone withdrawal syndromes - Pathophysiology and clinical significance
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DOI：
10.1016/s0094-0143(05)70389-x
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发表时间：
1997-05-01
影响因子：
2.4
通讯作者：
Scher, HI
中科院分区：
文献类型：
--
作者：
Kelly, WK;Slovin, S;Scher, HI
现在的数据证实，30% 的患者对停用类固醇激素作为原发性激素衰竭后的第一个策略有有意义的主观、生化和客观反应。这种综合征最初是在接受氟他胺治疗的患者中发现的，但现在的经验表明，这是一种更普遍的现象，涉及类固醇激素超家族的其他成员。这种效应的原因尚不清楚，但研究表明雄激素受体起着关键作用。
Data now confirm that 30% of patients have meaningful subjective, biochemical, and objective responses to the withdrawal of steroid hormone as the first maneuver after primary hormonal failure. This syndrome initially was recognized in patients treated with flutamide, but experience now suggests that this is a more generalized phenomenon that involves the other members of the steroid hormone superfamily. The cause of this effect is unknown, but studies suggest that the androgen receptor plays a critical role.