Tandem Mass-Selective Cryogenic Digital Ion Traps for Enhanced Cluster Formation
Tandem Mass-Selective Cryogenic Digital Ion Traps for Enhanced Cluster Formation
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DOI：
10.1021/acs.jpca.3c04706
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发表时间：
2023-09-01
影响因子：
2.9
通讯作者：
Garand，Etienne
中科院分区：
文献类型：
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作者：
Roesch，Gina C.;Garand，Etienne
我们提出了串联质量选择低温离子阱的实现，旨在增强离子处理能力的范围，可以在光谱询问之前执行。我们证明了离子簇的形成和质量过滤步骤可以结合在一个低温线性四极离子阱中，由射频方波驱动。质量滤波和质量隔离可以通过操纵射频频率和占空比来实现。非常重要的是，该方案避免了对可能与典型低温离子处理条件不兼容的高振幅射频电压的需求。此外，在聚类过程中适当调整稳定性边界可以优先形成特定的簇大小，而不是广泛的大小分布。最后，我们证明了一个特定的簇大小可以形成，大量选择，然后转移到另一个离子阱进行第二个完全独立的离子处理步骤。这里开发的仪器和模块化设计扩大了离子种类和簇的范围，可以通过处理电喷涂离子来访问。
We present the implementation of tandem mass-selective cryogenic ion traps, designed to enhance the range of ion processing capabilities that can be performed prior to spectroscopic interrogation. We show that both the formation of ion clusters and mass filtering steps can be combined in a single cryogenic linear quadrupole ion trap driven by RF square waves. Mass filtering and mass isolation can be achieved by manipulation of the RF frequency and duty cycle. Very importantly, this scheme circumvents the need for high-amplitude RF voltages that can be incompatible with typical cryogenic ion processing conditions. In addition, proper adjustment of the stability boundaries during the clustering process allows for the preferential formation of a specific cluster size rather than a broad distribution of sizes. Lastly, we show that a specific cluster size can be formed, mass-selected, and then transferred to another ion trap for a second completely separate ion processing step. The instrumentation and modular design developed here expand the scope of ionic species and clusters that can be accessed by processing electrosprayed ions.