Hemodialysis therapy for psoriasis.
Hemodialysis therapy for psoriasis.
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血液透析治疗牛皮癣。
DOI：
10.1111/j.1525-1594.1982.tb04049.x
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发表时间：
1982
影响因子：
2.4
通讯作者：
L. Sharma
中科院分区：
文献类型：
--
作者：
K. Chugh;B. Kumar;S. Pareek;V. Kher;P. Singhal;M. Lal;L. Sharma
对 25 名对常规治疗耐药的广泛斑块型银屑病患者进行了评估，以研究透析治疗对皮肤病变的影响。 20名患者每周使用1.0 m2 Cuprophan膜透析器透析两次，每次6小时。十八名患者对这种疗法有反应，皮肤病变消退。其中 12 例在 6 至 27 个月的随访期间未出现病变复发。两到六个月后，四名患者观察到一些新的病变，但这些病变还没有严重到需要重新进行透析的程度。两名患者在停止透析治疗后两个月内出现复发。其中一名患者开始第二次透析，随后病变得到缓解。五名患者作为对照，在接受透析之前接受了其他治疗方式，包括假透析、超滤不透析或全身肝素化。虽然假透析和全身肝素化对随后对透析治疗有反应的皮肤病变没有影响，但超滤程序后牛皮癣部分消退。透析似乎在牛皮癣的治疗中具有明确的作用。
Twenty-five patients with extensive plaque psoriasis resistant to conventional treatment were evaluated for study of the effects of dialytic therapy on the skin lesions. Twenty patients were dialyzed twice a week for six hours each time with a 1.0 m2 Cuprophan membrane dialyzer. Eighteen patients responded to this therapy with regression of skin lesions. Twelve of them have not developed recurrence of lesions during a followup period extending from 6 to 27 months. A few new lesions were observed after two to six months in four patients, but the lesions were not severe enough to justify reinstitution of dialysis. Two patients developed relapse within two months after cessation of dialytic therapy. One of them was started on dialysis a second time and this was followed by remission of lesions. Five patients were taken as controls and were treated with other modes of therapy including sham dialysis, ultrafiltration without dialysis, or systemic heparinization before they were taken on the dialysis program. Whereas sham dialysis and systemic heparinization had no effect on the skin lesions which responded later to dialytic therapy, the ultrafiltration procedure was followed by partial regression of psoriasis. Dialysis appears to have a definite role in the treatment of psoriasis.