Hormone replacement therapy, reproductive factors, and age-related macular degeneration:: The Salisbury eye evaluation project
Hormone replacement therapy, reproductive factors, and age-related macular degeneration:: The Salisbury eye evaluation project
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DOI：
10.1080/09286580490907779
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发表时间：
2005-02-01
影响因子：
1.8
通讯作者：
West, SK
中科院分区：
文献类型：
--
作者：
Freeman, EE;Muñoz, B;West, SK
目的：为了评估激素替代疗法（HRT），生殖因素和年龄相关性黄斑变性（AMD）之间的潜在关系，方法：1,458名女性参与者（年龄65-84岁）从索尔兹伯里眼睛评估研究可用于此横断面分析。AMD的结果通过眼底照片的阅读中心评估来确定。结果：目前使用HRT的女性有较低的调整后的大玻璃疣几率（> 125 μ m）（OR = 0.5，95%CI 0.2-1.0）。HRT的使用与早期AMD或晚期AMD的患病率无统计学显著相关性，尽管比值比均远小于1。出生人数增加的妇女有较大的玻璃疣患病率（线性趋势检验，p = 0.03）。结论：目前使用HRT与较大玻璃疣的几率较低相关，这可能是晚期AMD的预测。HRT或生殖因素与早期或晚期AMD之间无统计学显著相关性。
Purpose: To evaluate a potential relationship between hormone replacement therapy (HRT), reproductive factors and age-related macular degeneration (AMD).Methods: 1,458 female participants (age 65-84) from the Salisbury Eye Evaluation study were available for this cross-sectional analysis. AMD outcomes were identified by reading center assessment of fundus photographs.Results: Women who currently used HRT had a lower adjusted odds of large drusen (> 125 mu m) (OR = 0.5, 95% CI 0.2-1.0). Use of HRT was not statistically significantly associated with the prevalence of early AMD or advanced AMD, although the odds ratios were all much less than 1. Women who had had an increased number of births had a greater prevalence of large drusen (test of linear trend, p = 0.03).Conclusions: Current use of HRT was associated with a lower odds of large drusen, which may be predictive of advanced AMD. No statistically significant correlations were found between HRT or reproductive factors and early or advanced AMD.