The changing landscape of respiratory syncytial virus.
The changing landscape of respiratory syncytial virus.
复制标题
呼吸道合胞病毒不断变化的景观。
DOI：
10.1016/j.vaccine.2015.06.119
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发表时间：
2015
期刊：
影响因子：
5.5
通讯作者：
Polack,FernandoP
中科院分区：
文献类型：
--
作者：
Polack,FernandoP
近年来，对呼吸道合胞病毒（RSV）下呼吸道感染（LRTI）的急性和慢性负担的认识引发了一波开发针对该病原体的预防和治疗产品的倡议。RSV是工业化国家和发展中国家婴儿住院的主要原因，与儿童期反复喘息有因果关系，与小儿哮喘相关，并且是发展中国家婴儿出生后头几个月死亡的重要原因。随着新型RSV预防策略的出现，LRTI的流行病学、临床表现和严重后果可能在未来十年出现显著变化。本文概述了其中的一些变化，并根据当前文献和其他病原体的经验讨论了潜在的情况。
Recognition of the acute and chronic burden of respiratory syncytial virus (RSV) lower respiratory tract infections (LRTI) sparked a wave of initiatives to develop preventive and therapeutic products against the pathogen in recent years. RSV is a leading cause of hospitalization in infants in industrialized and developing countries, has been causally linked to recurrent wheezing during childhood, associated with pediatric asthma, and is an important cause of mortality in the first months of life in the developing world. Significant changes in the epidemiology, clinical manifestations, and severe consequences of LRTI may emerge in the next decade with the advent of novel preventive strategies against RSV. This manuscript outlines some of these changes and discusses potential scenarios based on the current literature and experiences with other pathogens.