A pH-sensitive and biodegradable supramolecular hydrogel constructed from a PEGylated polyphosphoester-doxorubicin prodrug and α-cyclodextrin
A pH-sensitive and biodegradable supramolecular hydrogel constructed from a PEGylated polyphosphoester-doxorubicin prodrug and α-cyclodextrin
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由聚乙二醇化聚磷酸酯-阿霉素前药和 α-环糊精构建的 pH 敏感且可生物降解的超分子水凝胶
DOI：
10.1039/c5py00620a
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发表时间：
2015-01-01
影响因子：
4.6
通讯作者：
Ni, Peihong
中科院分区：
文献类型：
--
作者：
Li, Fei;He, Jinlin;Ni, Peihong
通过开环聚合（ROP）和Cu(I)催化叠氮-炔环加成（CuAAC）“点击”化学反应，制备了一种酸不稳定聚乙二醇化多柔比星前药（pbypo -g- peg -g- dox）。得到的多功能前药与α -环糊精（α - cd）相互作用，制备了一种基于包合络合的新型超分子水凝胶。
An acid-labile and PEGylated polyphosphoester-doxorubicin prodrug (PBYP-g-PEG-g-DOX) was prepared via a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) "click" chemistry. The resulting multifunctional prodrug was then used to interact with alpha-cyclodextrin (alpha-CD) to fabricate a novel supramolecular hydrogel based on inclusion complexation.