When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?
When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?
复制标题
当抗衰老研究符合癌症化学预防时：抗衰老剂可以用一击杀死两只鸟吗？
DOI：
10.1007/s40495-015-0039-5
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发表时间：
2015-12-01
影响因子：
--
通讯作者：
Zi X
中科院分区：
文献类型：
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作者：
Yokoyama NN;Denmon A;Uchio EM;Jordan M;Mercola D;Zi X
最近的证据有力地支持，衰老的速度至少在一定程度上是由从蠕虫到人类的进化保守的营养传感途径（例如胰岛素/IGF-1信号传导，mTOR，AMPK和sirtuins）控制的。这些途径也通常参与致癌作用和癌症代谢。靶向这些营养感应途径的药物（例如二甲双胍、白藜芦醇和红景天）通常具有抗衰老和抗癌功效。这些药物不仅重新编程恶性细胞的能量代谢，而且通过抑制正常有丝分裂后细胞转化为衰老细胞来靶向它们，这赋予系统性代谢益处。这些药物与化疗（如紫杉醇和多柔比星）或放疗有根本的不同，后者会导致分子损伤（如DNA和蛋白质损伤），因此预期不会产生选择抗性。通过回顾作用的分子机制、流行病学证据、肿瘤模型的实验数据和早期临床研究结果，本文提供了支持具有抗衰老和抗癌功效的药物用于癌症化学预防的有希望的使用的信息。
Recent evidence has strongly supported that the rate of aging is controlled, at least to some extent, by evolutionarily conserved nutrient sensing pathways (e.g. the insulin/IGF-1-signaling, mTOR, AMPK, and sirtuins) from worms to humans. These pathways are also commonly involved in carcinogenesis and cancer metabolism. Agents (e.g. metformin, resveratrol, and Rhodiola) that target these nutrient sensing pathways often have both anti-aging and anti-cancer efficacy. These agents not only reprogram energy metabolism of malignant cells, but also target normal postmitotic cells by suppressing their conversion into senescent cells, which confers systematic metabolism benefits. These agents are fundamentally different from chemotherapy (e.g. paclitaxel and doxorubicin) or radiation therapy that causes molecular damage (e.g. DNA and protein damages) and thereby no selection resistance may be expected. By reviewing molecular mechanisms of action, epidemiological evidence, experimental data in tumor models, and early clinical study results, this review provides information supporting the promising use of agents with both anti-aging and anti-cancer efficacy for cancer chemoprevention.