Ghrelin strongly stimulates growth hormone (GH) release in humans
Ghrelin strongly stimulates growth hormone (GH) release in humans
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DOI：
10.1210/jc.85.12.4908
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发表时间：
2000-12-01
影响因子：
5.8
通讯作者：
Nakao, K
中科院分区：
文献类型：
--
作者：
Takaya, K;Ariyasu, H;Nakao, K
Ghrelin 是最近发现的 GH 促分泌受体的内源性配体，参与调节 GH 释放的新系统。然而，人们对其 GH 释放活性和对人类的其他内分泌影响知之甚少。为了解决这个问题，我们研究了 GH、ACTH、皮质醇、PRL、LH、FSH 和 TSH 对合成人生长素释放肽的反应。在四名正常男性成人（28-37 岁）中，静脉注射生长素释放肽以剂量依赖性方式释放 GH，0.2、1.0 和 5.0 微克/千克生长素释放肽在 30 分钟时分别产生 43.3 +/- 6.0、81.5 +/- 12.7 和 107.0 +/- 10.7 ng/mL 的 GH 峰值。注射生长素释放肽后，促肾上腺皮质激素、皮质醇和催乳素水平也升高，而最低剂量（0.2 微克/千克）仅导致这些激素的峰值最小（分别为 22.8 +/- 3.0 pg/mL、9.4 +/- 1.9 微克/分升和 4.6 +/- 0.6 纳克/毫升）。 LH、FSH 或 TSH 水平没有显着变化。这是第一项研究显示生长素释放肽强烈刺激人类生长激素释放。
Ghrelin is a recently identified endogenous ligand for the GH secretagogue receptor and is involved in a novel system for regulating GH release. However, little is known about its GH-releasing activity and other endocrine effects in humans. To address this issue, we studied the GH, ACTH, cortisol, PRL, LH, FSH, and TSH responses to synthetic human ghrelin. In four normal male adults (28-37 yr), iv ghrelin administration released GH in a dose-dependent manner and 0.2, 1.0, and 5.0 mug/kg ghrelin produced 43.3 +/- 6.0, 81.5 +/- 12.7, and 107.0 +/- 10.7 ng/mL of the GH peak values at 30 min, respectively. ACTH, cortisol, and PRL levels were also elevated after ghrelin injection, while the lowest dose (0.2 mug/kg) resulted in only minimum peak values of these hormones (22.8 +/- 3.0 pg/mL, 9.4 +/- 1.9 mug/dL, and 4.6 +/- 0.6 ng/mL, respectively). There were no significant changes in LH, FSH, or TSH levels. This is the first study showing evidence that ghrelin strongly stimulates GH release in humans.