The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development.
The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development.
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DOI：
10.1155/2012/507874
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发表时间：
2012
影响因子：
2.2
通讯作者：
Bellio M
中科院分区：
文献类型：
--
作者：
Rodrigues MM;Oliveira AC;Bellio M
在过去的十年中，研究表明，Toll样受体（TLR）家族成员识别克氏锥虫相关的分子模式，并证明了不同TLR在实验感染这种寄生虫期间的重要参与。在本综述中，我们将重点介绍TLR激活的途径在调节先天性和获得性免疫反应中的作用。cruzi感染，以及讨论针对恰加斯病（或美洲锥虫病）病原体的疫苗研究和开发的最新技术水平。
In the past ten years, studies have shown the recognition of Trypanosoma cruzi-associated molecular patterns by members of the Toll-like receptor (TLR) family and demonstrated the crucial participation of different TLRs during the experimental infection with this parasite. In the present review, we will focus on the role of TLR-activated pathways in the modulation of both innate and acquired immune responses to T. cruzi infection, as well as discuss the state of the art of vaccine research and development against the causative agent of Chagas disease (or American trypanosomiasis).