LOCALIZATION OF XP21 MEIOTIC EXCHANGE POINTS IN DUCHENNE MUSCULAR-DYSTROPHY FAMILIES
LOCALIZATION OF XP21 MEIOTIC EXCHANGE POINTS IN DUCHENNE MUSCULAR-DYSTROPHY FAMILIES
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DOI：
10.1136/jmg.23.6.531
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发表时间：
1986-12-01
影响因子：
4
通讯作者：
KUNKEL, LM
中科院分区：
文献类型：
--
作者：
BERTELSON, CJ;BARTLEY, JA;KUNKEL, LM
对25个Duchenne型肌营养不良症家系进行了Xp21及其周围10个座位的13个X染色体特异性DNA片段的遗传研究。当多个探针提供信息时，每个减数分裂的减数分裂交换点位于单个家系中。无论是遗传还是物理证据都没有表明在这25个家庭中Xp21存在异常高的重组率。
The inheritance of Duchenne muscular dystrophy in 25 families was studied with 13 X chromosome specific cloned DNA fragments from 10 loci in and surrounding Xp21. When multiple probes were informative, the meiotic exchange points for each meiosis were located in individual families. Neither genetic nor physical evidence indicates an unusually high recombination rate across Xp21 in these 25 families.