Antimicrobial resistance in Escherichia coli isolates from food animals, animal food products and companion animals in China
Antimicrobial resistance in Escherichia coli isolates from food animals, animal food products and companion animals in China
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中国食用动物、动物食品和伴侣动物中分离出的大肠杆菌的耐药性。
DOI：
10.1016/j.vetmic.2010.04.025
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发表时间：
2010-11-20
影响因子：
3.3
通讯作者：
Liu, Jian-Hua
中科院分区：
文献类型：
--
作者：
Lei, Tao;Tian, Wei;Liu, Jian-Hua
采用标准琼脂稀释法，对2007 - 2008年华南地区食用动物、动物源性食品和伴侣动物分离的1030株大肠埃希菌进行了14种抗菌药物的敏感性研究。70%以上的菌株对四环素、复方新诺明、萘啶酸和氨苄青霉素耐药。一般而言，伴侣动物分离株中的耐药率低于食用动物分离株，但伴侣动物分离株中头孢菌素和阿米卡星耐药率更高，分别为42.6%至56.2% vs 14.1%至24.3%和28.5% vs 18.8%，这很可能是由于这些抗菌药物常用于宠物动物治疗。所有动物分离株对氟喹诺酮类药物的耐药率均较高（>50%）。来自这三种资源的菌株对食品的耐药性最低。PFGE分析表明，大多数多药耐药大肠埃希氏菌是耐药大肠埃希氏菌。大肠杆菌分离株显示出独特的，不相关的PFGE图谱，不太可能是一个特定的克隆传播。本研究为了解大肠埃希菌的耐药性提供了有用的信息。对中国动物和食品中分离的大肠杆菌进行了鉴定，为动物抗菌药物的使用与细菌分离株的抗菌药物耐药性选择之间的联系提供了证据。这项研究的数据进一步警告在食品和宠物动物中谨慎使用抗菌剂，以减少将耐药性人畜共患病病原体传播给人类的风险。(C)2010 Elsevier B. V.保留所有权利。
One thousand and thirty Escherichia coli isolates from food animals, animals-derived foods, and companion animals between 2007 and 2008 in Southern China were used to investigate their antimicrobial susceptibility to 14 different antimicrobials by the standard agar dilution method. More than 70% of isolates showed resistance to tetracycline, trimethoprim-sulphamethoxazole, nalidixic acid, and ampicillin. In general, resistance was less frequent in companion animal isolates vs food animals isolates, but cephalosporin and amikacin resistance was more frequent in companion animal isolates, 42.6% to 56.2% vs 14.1% to 24.3%, and 28.5% vs 18.8%, respectively, which was most likely due to the common use of these antimicrobials as treatment in pet animals. Fluroquinolones resistance was high in all animal isolates (>50%). Food products showed lowest resistance among isolates from these three resources. PFGE analysis indicated that a majority of multidrug-resistant E. coli isolates showed unique, unrelated PFGE profiles and were unlikely to be the spread of a specific clone. This study provides useful information about the prevalence of antimicrobial resistance in E. coli isolated from animals and food products in China and provided evidence of the linkage of the use of antimicrobials in animals and its selection of antimicrobial resistance in bacterial isolates. The data from this study further warns the prudent use of antimicrobials in food and pet animals to reduce the risks of transmission of antimicrobial resistance zoonotic pathogen to humans. (C) 2010 Elsevier B.V. All rights reserved.