Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome.
Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome.
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DOI：
10.1128/mbio.01951-16
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发表时间：
2016-11-15
期刊：
影响因子：
6.4
通讯作者：
Ghannoum M
中科院分区：
文献类型：
--
作者：
Ghannoum M
不愈合的慢性伤口在起源和情况上都是独特的，试图找出伤口无法愈合的单一病因是令人畏惧的。伤口代表了多种真菌和细菌生物膜的复杂系统。互动微生物群落的生存策略导致了合作进化策略，最终形成生物膜。在微生物失调中，生物膜对细菌和真菌群落都有好处，但对宿主有害。真菌受益于其毒力因子的激增，而细菌由于生活在生物膜基质的保护伞下而变得对抗菌药物具有耐受性。这种界间合作对宿主产生负面影响，因为真菌和细菌产生细胞外酶，造成组织损伤，导致促炎细胞因子增加，从而导致氧化损伤和细胞凋亡。
Nonhealing chronic wounds are all unique in origin and circumstance, and attempting to isolate a single etiology for the failure of a wound to heal is daunting. Wounds represent complex systems of multispecies fungal and bacterial biofilms. The survival strategies of interactive microbial communities have led to cooperative evolutionary strategies that culminate in biofilm formation. In microbial dysbiosis, biofilms are beneficial to both bacterial and fungal communities but detrimental to the host. Fungi benefit by a surge in their virulence factors, while bacteria become tolerant to antibacterials as a consequence of living under the protective umbrella of the biofilm matrix. This interkingdom cooperation negatively impacts the host, as the fungi and bacteria produce extracellular enzymes that inflict tissue damage, leading to an increase in proinflammatory cytokines, which results in oxidative damage and apoptotic cell death.