Enantiomer-specific bioaccumulation and depuration of hexabromocyclododecanes in zebrafish (Danio Rerio)
Enantiomer-specific bioaccumulation and depuration of hexabromocyclododecanes in zebrafish (Danio Rerio)
复制标题
斑马鱼 (Danio Rerio) 中六溴环十二烷的对映体特异性生物富集和净化
DOI：
10.1016/j.jhazmat.2012.12.046
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发表时间：
2013-03-15
影响因子：
13.6
通讯作者：
Zhang, Xian
中科院分区：
文献类型：
--
作者：
Du, Miaomiao;Lin, Lifeng;Zhang, Xian
研究了6种六溴环十二烷对映体在斑马鱼体内的生物富集和净化过程。（+/-）α-六溴环十二烷、（+/-）β-六溴环十二烷和（+/-）γ-六溴环十二烷的生物累积具有浓度依赖性。从他们的浓度趋势和同化效率的结果表明，斑马鱼选择性生物积累的（+）α-对映体和（+）γ-对映体相比，其相应的（-）-对映体。然而，（+/-）β-六溴环十二烷在生物累积过程中没有表现出对映选择性。除低剂量的（-）γ-六溴环十二烷外，所有六种对映异构体在斑马鱼体内的分布均遵循一级动力学。这些结果表明，六溴环十二烷在斑马鱼体内的生物累积和降解具有对映体选择性。不同的六溴环十二烷对映体在生物体内表现出不同的生物学过程。(C)2013 Elsevier B. V.保留所有权利。
The bioaccumulation and depuration of six hexabromocyclododecane enantiomers in zebrafish were investigated through dietary exposure. The bioaccumulation of (+/-)alpha-HBCD, (+/-)beta-HBCD and (+/-)gamma-HBCD was concentration dependent. The results from their concentration trends and assimilation efficiencies suggested that zebrafish selectively bioaccumulate the (+) alpha-enantiomer and (+) gamma-enantiomer compared to their corresponding (-)-enantiomers. However, (+/-)beta-HBCD did not show enantioselectivity in the process of bioaccumulation. The deputation of all six enantiomers in zebrafish followed first-order kinetics except (-)gamma-HBCD in low dose. These results showed that the bioaccumulation and deputation of HBCDs in zebrafish were enantiomer-selective. Each enantiomeric pair of HBCDs could display different biological process in organisms. (C) 2013 Elsevier B.V. All rights reserved.