A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration.
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration.
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DOI：
10.3791/53266
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发表时间：
2016-01-22
期刊：
影响因子：
--
通讯作者：
Wilden JA
中科院分区：
文献类型：
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作者：
Batra V;Guerin GF;Goeders NE;Wilden JA
药物使用障碍，特别是甲基苯丙胺，是一种毁灭性的复发性疾病，对年轻人的影响尤为严重。需要在动物模型中验证的新颖、有效和实用的治疗策略。神经调节，包括脑深部电刺激（DBS）疗法，是指使用电来影响病理性神经元活动，并已显示出对精神疾病（包括药物依赖）的希望。DBS在临床实践中涉及使用植入式起搏器样系统将刺激持续输送到大脑结构中，该系统由医生在外部编程以缓解症状。由于具有挑战性的心理社会状况，这种治疗将仅限于甲基苯丙胺使用者。可以间歇性地、非侵入性地和远程地从药物使用环境中提供的电治疗将更加现实。本文描述了颅内电刺激的递送，其在时间和空间上与用于治疗IV甲基苯丙胺依赖的药物使用环境分离。啮齿类动物使用静脉内（IV）自我给药的操作模式迅速形成甲基苯丙胺依赖，该模式包括一段时间的延长药物获取时间，并表现出使用升级和获得药物的高度动机。
Substance use disorders, particularly to methamphetamine, are devastating, relapsing diseases that disproportionally affect young people. There is a need for novel, effective and practical treatment strategies that are validated in animal models. Neuromodulation, including deep brain stimulation (DBS) therapy, refers to the use of electricity to influence pathological neuronal activity and has shown promise for psychiatric disorders, including drug dependence. DBS in clinical practice involves the continuous delivery of stimulation into brain structures using an implantable pacemaker-like system that is programmed externally by a physician to alleviate symptoms. This treatment will be limited in methamphetamine users due to challenging psychosocial situations. Electrical treatments that can be delivered intermittently, non-invasively and remotely from the drug-use setting will be more realistic. This article describes the delivery of intracranial electrical stimulation that is temporally and spatially separate from the drug-use environment for the treatment of IV methamphetamine dependence. Methamphetamine dependence is rapidly developed in rodents using an operant paradigm of intravenous (IV) self-administration that incorporates a period of extended access to drug and demonstrates both escalation of use and high motivation to obtain drug.