A Cuff Lead for Delivering Ionic Direct Current (iDC) to Block Neural Activities of Sciatic Nerve.
A Cuff Lead for Delivering Ionic Direct Current (iDC) to Block Neural Activities of Sciatic Nerve.
复制标题
用于输送离子直流电 (iDC) 以阻断坐骨神经神经活动的袖带导线。
DOI：
10.1109/embc40787.2023.10340183
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Fridman,GY
中科院分区：
文献类型：
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作者：
Cheng,C;Foxworthy,GE;Fridman,GY
细胞外施加直流电(DC)可阻断动作电位(AP)在神经元中的传播。这种抑制模式已经被提出作为一种可能的治疗方法来阻断伤害性疼痛。然而，由于金属电极上电化学反应的演化对电荷注入的限制，DC的应用在持续时间上受到限制。为了延长直流电的应用范围，可以使用填充了导电电解液的微流控导线将金属电极与靶神经分离。在这里，我们描述了一种由生物相容硅胶制成的三极神经袖带导线，用于阻断大鼠坐骨神经中的AP。这种引线具有自我卷曲的硅胶膜，用于包裹坐骨神经，以确保神经与周围肌肉之间的机械连接和电气隔离。体内测试表明，通过袖带导线输送1.4 mA的DC阻断了神经活动，并将诱发的复合动作电位(ECAP)降低到其非阻断反应的30%。
Direct current (DC) applied extracellularly can block action potential (AP) propagation in a neuron. This suppression paradigm has been proposed as a possible treatment for blocking nociceptive pain. However, the application of DC is limited in duration due to the charge injection constraint imposed by the evolution of electrochemical reactions at the metal electrode. To prolong the application of DC, a microfluidic lead filled with conductive electrolyte can be used to separate the metal electrode from the target nerve. Here, we describe a tripolar nerve cuff lead fabricated with biocompatible silicone to block the APs in the rat sciatic nerve. This lead has a self-curling silicone membrane to wrap around sciatic nerve for secured mechanical attachment and electrical isolation between the nerve and the surrounding muscle. In-vivo testing showed that delivering 1.4mA DC via the cuff lead blocked the nerve activity and reduced the evoked compound action potential (eCAP) to 30% of its unblocked response.