Entropic depletion of DNA in triangular nanochannels.
Entropic depletion of DNA in triangular nanochannels.
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DOI：
10.1063/1.4794371
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发表时间：
2013-03
期刊：
影响因子：
3.2
通讯作者：
Wesley F. Reinhart;Douglas R. Tree;K. Dorfman
中科院分区：
文献类型：
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作者：
Wesley F. Reinhart;Douglas R. Tree;K. Dorfman
使用Monte Carlo模拟的触摸珠模型的双链DNA，我们表明，DNA的延伸增强等腰三角形纳米通道（相对于一个圆形的纳米通道相同的有效尺寸），由于在通道角落的熵耗尽。增强的延伸的程度非单调地取决于纳米通道的可达面积和三角形的顶角。我们还开发了一种度量来量化熵耗尽的程度，从而将圆形，方形和各种三角形纳米通道的延伸数据折叠到Odijk和de Gennes政权之间过渡的通道尺寸的单个主曲线上。
Using Monte Carlo simulations of a touching-bead model of double-stranded DNA, we show that DNA extension is enhanced in isosceles triangular nanochannels (relative to a circular nanochannel of the same effective size) due to entropic depletion in the channel corners. The extent of the enhanced extension depends non-monotonically on both the accessible area of the nanochannel and the apex angle of the triangle. We also develop a metric to quantify the extent of entropic depletion, thereby collapsing the extension data for circular, square, and various triangular nanochannels onto a single master curve for channel sizes in the transition between the Odijk and de Gennes regimes.