NEMA NU-4 performance evaluation of a non-human primate animal PET
NEMA NU-4 performance evaluation of a non-human primate animal PET
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非人类灵长类动物 PET 的 NEMA NU-4 性能评估
DOI：
10.1088/1361-6560/ab1614
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发表时间：
2019-05-01
影响因子：
3.5
通讯作者：
Wei Long
中科院分区：
文献类型：
--
作者：
Chai Pei;Feng Baotong;Wei Long
Eplus-260灵长类动物PET是中国科学院高能物理研究所研制的一种动物PET成像系统，用于对非人类灵长类动物，特别是大型非人类灵长类动物的大脑进行成像。该系统由48个块探测器组成，排列在两个24边环中，环直径为263毫米，轴向范围为64毫米。每个块探测器由一个16 x 16掺铈的镥钇正硅酸盐晶体阵列组成，像素尺寸为1.9 x 1.9 x 10 mm(3)。本文根据美国电气制造商协会NU-4 2008标准对PET扫描仪进行了性能评估。所有的测量都是在360-660 keV的能量窗和2 ns的重合时间窗下进行的。在FWHM方面，FBP重建的空间分辨率结果在5 mm径向位置三个方向均优于或接近2 mm，在视场中心5 cm直径范围内保持在3.0 mm以下。扫描仪的峰值绝对灵敏度为1.80%。对于猴子大小的幻影，散射分数为34.2%，峰值噪声等效计数率（NECR）为26.5 kcps，为64.3 kBq/cc。扫描仪的整体成像能力也通过恒河猴的体内成像研究进行了评估。性能测量表明，Eplus-260灵长类动物PET扫描仪具有获得非人类灵长类动物高质量和高对比度图像的潜在能力，特别是大型非人类灵长类动物的大脑，可以被认为是当今技术先进的专用非人类灵长类动物PET扫描仪。
The Eplus-260 primate PET is an animal PET imaging system developed by the Institute of High Energy Physics, Chinese Academy of Sciences, which is designed to image non-human primates, especially the brain of large non-human primates. The system consists of 48 block detectors arranged in two 24-sided rings with a ring diameter of 263 mm and an axial extent of 64 mm. Each block detector is composed of a 16 x 16 cerium-doped lutetium-yttrium orthosilicate crystal array with a pixel size of 1.9 x 1.9 x 10 mm(3). This article presents a performance evaluation of the PET scanner according to the National Electrical Manufacturers Association NU-4 2008 standards. All measurements were made for an energy window of 360-660 keV and a coincidence timing window of 2 ns. In terms of the FWHM, the FBP reconstructed spatial resolution results in all three directions at the radial position of 5 mm were better than or approached to 2 mm, and remained below 3.0 mm within the central 5 cm diameter of the FOV. The peak absolute sensitivity of the scanner was measured 1.80%. For a monkey-sized phantom, the scatter fraction was 34.2% and the peak noise equivalent count rate (NECR) was 26.5 kcps at 64.3 kBq/cc. The overall imaging capabilities of the scanner were also assessed using in vivo imaging study of a rhesus macaque. The performance measurements demonstrate that the Eplus-260 primate PET scanner has the potential ability to obtain good quality and high-contrast images for non-human primates, especially the brain of large non-human primates and could be considered as one technologically advanced dedicated non-human primate PET scanner available today.