Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
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DOI：
10.1038/ng.209
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发表时间：
2008-09
期刊：
影响因子：
30.8
通讯作者：
Craddock, Nick
中科院分区：
文献类型：
--
作者：
Ferreira, Manuel A. R.;O'Donovan, Michael C.;Meng, Yan A.;Jones, Ian R.;Ruderfer, Douglas M.;Jones, Lisa;Fan, Jinbo;Kirov, George;Perlis, Roy H.;Green, Elaine K.;Smoller, Jordan W.;Grozeva, Detelina;Stone, Jennifer;Nikolov, Ivan;Chambert, Kimberly;Hamshere, Marian L.;Nimgaonkar, Vishwajit L.;Moskvina, Valentina;Thase, Michael E.;Caesar, Sian;Sachs, Gary S.;Franklin, Jennifer;Gordon-Smith, Katherine;Ardlie, Kristin G.;Gabriel, Stacey B.;Fraser, Christine;Blumenstiel, Brendan;Defelice, Matthew;Breen, Gerome;Gill, Michael;Morris, Derek W.;Elkin, Amanda;Muir, Walter J.;McGhee, Kevin A.;Williamson, Richard;MacIntyre, Donald J.;MacLean, Alan W.;Clair, David St;Robinson, Michelle;Van Beck, Margaret;Pereira, Ana C. P.;Kandaswamy, Radhika;McQuillin, Andrew;Collier, David A.;Bass, Nicholas J.;Young, Allan H.;Lawrence, Jacob;Ferrier, I. Nicol;Anjorin, Adebayo;Farmer, Anne;Curtis, David;Scolnick, Edward M.;McGuffin, Peter;Daly, Mark J.;Corvin, Aiden P.;Holmans, Peter A.;Blackwood, Douglas H.;Gurling, Hugh M.;Owen, Michael J.;Purcell, Shaun M.;Sklar, Pamela;Craddock, Nick
为了确定双相情感障碍的易感基因位点，我们在4387例患者和6209例对照中检测了180万个变异，并且在ANK3（锚蛋白G）中确定了一个强关联区域（rs10994336，P = 9.1×10⁻⁹）。我们还发现了对先前报道的CACNA1C（L型电压门控钙通道的α1C亚单位；联合P = 7.0×10⁻⁸，rs1006737）的进一步支持。我们的结果表明离子通道病可能参与双相情感障碍的发病机制。
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10-9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 × 10-8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
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影响因子：
4.5
作者：
Evans, David M.;Marchini, Jonathan;Morris, Andrew P.;Cardon, Lon R.
通讯作者：
Cardon, Lon R.
影响因子：
11
作者：
Baum, A. E.;Akula, N.;McMahon, F. J.
通讯作者：
McMahon, F. J.
影响因子：
11
作者：
Sklar, P.;Smoller, J. W.;Purcell, S. M.
通讯作者：
Purcell, S. M.
影响因子：
30.8
作者：
Rioux, John D.;Xavier, Ramnik J.;Brant, Steven R.
通讯作者：
Brant, Steven R.
影响因子：
64.8
作者：
Burton, Paul R.;Clayton, David G.;Cardon, Lon R.;Craddock, Nick;Deloukas, Panos;Duncanson, Audrey;Kwiatkowski, Dominic P.;McCarthy, Mark I.;Ouwehand, Willem H.;Samani, Nilesh J.;Todd, John A.;Donnelly, Peter;Barrett, Jeffrey C.;Davison, Dan;Easton, Doug;Evans, David;Leung, Hin-Tak;Marchini, Jonathan L.;Morris, Andrew P.;Spencer, Chris C. A.;Tobin, Martin D.;Attwood, Antony P.;Boorman, James P.;Cant, Barbara;Everson, Ursula;Hussey, Judith M.;Jolley, Jennifer D.;Knight, Alexandra S.;Koch, Kerstin;Meech, Elizabeth;Nutland, Sarah;Prowse, Christopher V.;Stevens, Helen E.;Taylor, Niall C.;Walters, Graham R.;Walker, Neil M.;Watkins, Nicholas A.;Winzer, Thilo;Jones, Richard W.;McArdle, Wendy L.;Ring, Susan M.;Strachan, David P.;Pembrey, Marcus;Breen, Gerome;St Clair, David;Caesar, Sian;Gordon-Smith, Katherine;Jones, Lisa;Fraser, Christine;Green, Elain K.;Grozeva, Detelina;Hamshere, Marian L.;Holmans, Peter A.;Jones, Ian R.;Kirov, George;Moskvina, Valentina;Nikolov, Ivan;O'Donovan, Michael C.;Owen, Michael J.;Collier, David A.;Elkin, Amanda;Farmer, Anne;Williamson, Richard;McGuffin, Peter;Young, Allan H.;Ferrier, I. Nicol;Ball, Stephen G.;Balmforth, Anthony J.;Barrett, Jennifer H.;Bishop, D. Timothy;Iles, Mark M.;Maqbool, Azhar;Yudasheve, Nadira;Hall, Alistair S.;Braund, Peter S.;Dixon, Richard J.;Mangino, Massimo;Stevens, Suzanne;Thompson, John R.;Bredin, Francesca;Tremelling, Mark;Parkes, Miles;Drummond, Hazel;Lees, Charles W.;Nimmo, Elaine R.;Satsangi, Jack;Fisher, Sheila A.;Forbes, Alistair;Lewis, Cathryn M.;Onnie, Clive M.;Prescott, Natalie J.;Sanderson, Jeremy;Mathew, Christopher G.;Barbour, Jamie;Mohiuddin, M. Khalid;Todhunter, Catherine E.;Mansfield, John C.;Ahmad, Tariq;Cummings, Fraser R.;Jewell, Derek P.;Webster, John;Brown, Morris J.;Lathrop, G. Mark;Connell, John;Dominiczak, Anna;Marcano, Carolina A. Braga;Burke, Beverley;Dobson, Richard;Gungadoo, Johannie;Lee, Kate L.;Munroe, Patricia B.;Newhouse, Stephen J.;Onipinla, Abiodun;Wallace, Chris;Xue, Mingzhan;Caulfield, Mark;Farrall, Martin;Barton, Anne;Bruce, Ian N.;Donovan, Hannah;Eyre, Steve;Gilbert, Paul D.;Hider, Samantha L.;Hinks, Anne M.;John, Sally L.;Potter, Catherine;Silman, Alan J.;Symmons, Deborah P. M.;Thomson, Wendy;Worthington, Jane;Dunger, David B.;Widmer, Barry;Frayling, Timothy M.;Freathy, Rachel M.;Lango, Hana;Perry, John R. B.;Shields, Beverley M.;Weedon, Michael N.;Hattersley, Andrew T.;Hitman, Graham A.;Walker, Mark;Elliott, Kate S.;Groves, Christopher J.;Lindgren, Cecilia M.;Rayner, Nigel W.;Timpson, Nicholas J.;Zeggini, Eleftheria;Newport, Melanie;Sirugo, Giorgio;Lynons, Emily;Vannberg, Fredrik;Brown, Matthew A.;Franklyn, Jayne A.;Heward, Joanne M.;Simmonds, Matthew J.;Hill, Adrian V. S.;Bradbury, Linda A.;Farrar, Claire;Pointon, Jennifer J.;Wordsmith, Paul;Gough, Stephen C. L.;Seal, Sheila;Stratton, Michael R.;Rahman, Nazneen;Ban, Maria;Goris, An;Sawcer, Stephen J.;Compston, Alistair;Conway, David;Jallow, Muminatou;Bumpstead, Suzannah J.;Chaney, Amy;Downes, Kate;Ghori, Mohammed J. R.;Gwilliam, Rhian;Inouye, Michael;Keniry, Andrew;King, Emma;McGinnis, Ralph;Potter, Simon;Ravindrarajah, Rathi;Whittaker, Pamela;Withers, David;Easton, Doug;Pereira-Gale, Joanne;Hallgrimsdottir, Ingilef B.;Howie, Bryan N.;Su, Zhan;Teo, Yik Ying;Vukcevic, Damjan;Bentley, David;Caulfield, Mark;Mathew, Christopher G.;Worthington, Jane
通讯作者：
Worthington, Jane