CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans
CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans
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DOI：
10.1128/jb.01237-07
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发表时间：
2008-04-01
影响因子：
3.2
通讯作者：
Burne, Robert A.
中科院分区：
文献类型：
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作者：
Abranches, Jacqueline;Nascimento, Marcelle M.;Burne, Robert A.
CcpA在许多革兰氏阳性菌中响应于碳水化合物的可用性而全面调节转录，但其在变形链球菌中的作用仍然是个谜。利用S.作为一个模型，我们证明了CcpA在碳分解代谢物阻遏（CCR）中起着直接的作用。随后，170个基因的表达在葡萄糖生长的野生型（UA159）和CcpA缺陷型（TW1）菌株中显示出不同的表达（>= 2倍）（P
CcpA globally regulates transcription in response to carbohydrate availability in many gram-positive bacteria, but its role in Streptococcus mutans remains enigmatic. Using the fructan hydrolase (fruA) gene of S. mutans as a model, we demonstrated that CcpA plays a direct role in carbon catabolite repression (CCR). Subsequently, the expression of 170 genes was shown to be differently expressed (>= 2-fold) in glucose-grown wild-type (UA159) and CcpA-deficient (TW1) strains (P