Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese
Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese
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DOI：
10.1016/j.jad.2009.02.002
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发表时间：
2009-11-01
影响因子：
6.6
通讯作者：
Lin, Xu
中科院分区：
文献类型：
--
作者：
Pan, An;Lu, Ling;Lin, Xu
背景：维生素D缺乏最近被推测在抑郁症的发展中起作用，然而，很少有研究探索普通人群血液中25-羟基维生素D [25(OH)D]浓度与抑郁症之间的关系。因此，我们的目的是在中国中老年人群中确定这种关联。方法：我们于2005年在中国北京和上海进行了一项基于人群的横断面研究。参与者包括3262名年龄在50-70岁之间的社区居民。抑郁症状定义为流行病学研究中心抑郁量表（CES-D）得分为16分或更高。用放射免疫法测定循环25(OH)D浓度。结果：在研究人群中，25(OH)D浓度最高的生育组抑郁症状的患病率低于最低生育组（7.2%对11.1%）（优势比为0.62；95%可信区间为0.46-0.83；趋势P = 0.002）。在控制了各种混杂因素后，这种关联大大减弱，并在模型中加入地理位置后消失。在北京或上海的参与者中，按地点分层分析未发现抑郁症状与25(OH)D水平之间的任何关联。局限性：由于横断面研究设计，因果关系尚不清楚。结论：中国中老年人群抑郁症状与25(OH)D浓度无关。需要进一步的前瞻性研究来确定它们是否相关。(C) 2009 Elsevier B.V.版权所有
Background: Vitamin D deficiency is recently speculated to play a role in the development of depression, Nevertheless, few studies have explored the association between blood 25-hydroxyvitamin D [25(OH)D] concentrations and depression in the general population. Therefore, we aimed to determine this association in middle-aged and elderly Chinese.Methods: We conducted a population-based cross-sectional study in 2005 in Beijing and Shanghai, China. Participants included 3262 Community residents aged 50-70. Depressive symptoms were defined as a Center for Epidemiological Studies of Depression Scale (CES-D) score of 16 or higher.. Circulating 25(OH)D concentrations were measured by radioimmumoassay.Results: The prevalence of depressive symptoms was lower in the top fertile of 25(OH)D concentrations compared to the lowest tertile (7.2% vs. 11.1%) in the study population (odds ratio, 0.62; 95% confidence interval, 0.46-0.83; P for trend= 0.002). This association was substantially attenuated after controlling for various confounding factors, and disappeared after including geographic location in the model. Stratified analysis by location did not find any association between depressive symptoms and 25(OH)D levels among participants from either Beijing or Shanghai.Limitations: Due to the cross-sectional study design, causal relation remains unknown.Conclusions: Depressive symptoms are not associated with 25(OH)D concentrations in middle-aged and elderly Chinese. Further prospective Studies are required to determine whether they are correlated. (C) 2009 Elsevier B.V. All rights reserved.