Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats
Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats
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DOI：
10.1186/s13244-019-0824-5
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发表时间：
2020-02-04
影响因子：
4.7
通讯作者：
Maisano, Federico
中科院分区：
文献类型：
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作者：
Bussi, Simona;Coppo, Alessandra;Maisano, Federico
目的本研究的目的是比较累积暴露于四种市售大环钆基造影剂（GBCA）后大鼠组织中Gd水平。方法雄性SD大鼠65只，随机分为4个染毒组（每组15只）和1个对照组（每组5只）。每个暴露组的动物接受20次GBCA给药（每周4次ProHance（R）、多它灵（R）、Clariscan（TM）或Gadovist（R），连续5周），剂量为0.6 mmol/kg体重。恢复28天后，处死动物，收获组织，通过电感耦合等离子体质谱法（ICP-MS）测定Gd。对所有动物的肾组织进行组织学评估。结果显著（p
Objectives The purpose of this study was to compare Gd levels in rat tissues after cumulative exposure to four commercially available macrocyclic gadolinium-based contrast agents (GBCAs). Methods Sixty-five male Sprague-Dawley rats were randomized to four exposure groups (n = 15 per group) and one control group (n = 5). Animals in each exposure group received 20 GBCA administrations (four per week of ProHance (R), Dotarem (R), Clariscan (TM), or Gadovist (R) for 5 consecutive weeks) at a dose of 0.6 mmol/kg bodyweight. After 28-days' recovery, animals were sacrificed and tissues harvested for Gd determination by inductively coupled plasma-mass spectroscopy (ICP-MS). Histologic assessment of the kidney tissue was performed for all animals. Results Significantly (p