CD4 and CD8 counts are associated with interactions of gender and psychosocial stress.
CD4 and CD8 counts are associated with interactions of gender and psychosocial stress.
复制标题
CD4 和 CD8 计数与性别和社会心理压力的相互作用有关。
DOI：
10.1097/00006842-199809000-00023
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发表时间：
1998
影响因子：
3.3
通讯作者：
Borson,S
中科院分区：
文献类型：
--
作者：
Scanlan,JM;Vitaliano,PP;Ochs,H;Savage,MV;Borson,S
目的本研究探讨了性别、心理社会压力/痛苦的关系（抱怨、争吵、沮丧），以及两个老年人样本中CD 4和CD 8细胞的相对百分比和绝对细胞计数（平均年龄= 69.4）-阿尔茨海默病患者的配偶照顾者（N= 78）和年龄和性别匹配的非痴呆对照配偶（N= 72）方法在15- 18个月的时间内，对CD 4和CD 8细胞的计数和百分比以及心理社会变量进行了两次评估（时间1，时间2）。几个协变量进行了检查的分析，包括身体质量指数（BMI），药物使用，酒精使用，运动，和疾病history.ResultsCaregiver男性有较少的CD 4细胞计数在时间1和2比对照组男性（p<. 05）。05）。在第1和第2次，CD 8细胞计数和百分比与男性的麻烦呈正相关（p<0.05）。05），但不是在妇女。虽然在这两个时间的麻烦和性别的相互作用存在的CD 8的百分比，相互作用和主要影响不存在的CD 4的百分比在任何时间。当分析CD 4与CD 8水平的比率时，性别相互作用的麻烦在时间1和时间2都存在-麻烦与男性的CD 4/CD 8比率呈负相关（p<0.05）。05），但在女性无关。从时间1到时间2，变化分析显示，麻烦评分的增加与CD 4计数的减少相关（p<0.05）。而汉密尔顿抑郁评分的增加与CD 8计数和百分比的增加相关（p<0.05）。05).结论照顾者的地位，麻烦，抑郁情绪与CD 4和CD 8计数的横截面和/或纵向关联，但这种关系主要发生在男性。此外，绝对细胞计数与社会心理因素的关系比百分比更密切。
ObjectiveThis study examined relationships of gender, psychosocial stress/distress (caregiving, hassles, depressed mood), and the relative percentage and absolute cell counts of CD4 and CD8 cells in two samples of older adults (mean age= 69.4)-spouse caregivers of persons with Alzheimer's disease (N= 78) and age-and gender-matched spouses of nondemented controls (N= 72).MethodsCounts and percentages of CD4 and CD8 cells and psychosocial variables were assessed twice (Time 1, Time 2) over a 15-to 18-month period. Several covariates were examined in the analyses, including body mass index (BMI), medication use, alcohol use, exercise, and illness history.ResultsCaregiver men had fewer CD4 cell counts at Times 1 and 2 than did control men (p<. 05). At Times 1 and 2, both CD8 cell counts and percentages were positively associated with hassles in men (p<. 05), but not in women. Although interactions of hassles and gender were present for CD8 percentages at both times, interactions and main effects were not present for CD4 percentages at either time. When the ratio of CD4 to CD8 levels was analyzed, hassles by gender interactions were present at both Times 1 and 2-hassles were negatively associated with the CD4/CD8 ratio in men (p<. 05), but unrelated in women. From Time 1 to Time 2, change analyses showed that increases in hassles scores were associated with decreases in CD4 counts (p<. 05), whereas increases in Hamilton Depression Scores were related to increases in both CD8 counts and percentages (p<. 05).ConclusionCaregiver status, hassles, and depressed mood had cross-sectional and/or longitudinal associations with CD4 and CD8 counts, but such relationships occurred primarily in men. Moreover, absolute cell counts were more related to psychosocial factors than were percentages.