Strength through diversity.
Strength through diversity.
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DOI：
10.1016/j.neuron.2008.10.020
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发表时间：
2008-11-06
期刊：
影响因子：
16.2
通讯作者：
Turrigiano GG
中科院分区：
文献类型：
--
作者：
Nelson SB;Turrigiano GG
哺乳动物大脑的非凡多样性是由细胞可塑性机制的巨大多样性所实现的。这些包括兴奋性和抑制性突触的长时程增强和抑制，以及各种内在和稳态可塑性机制。该领域面临的一个根本挑战是将我们对这些特定机制的详细知识整合成一幅关于皮层回路内可塑性如何调节网络特性的连贯画面。
The remarkable versatility of the mammalian brain is made possible by a huge diversity of cellular plasticity mechanisms. These include long-term potentiation and depression at both excitatory and inhibitory synapses, as well as a variety of intrinsic and homeostatic plasticity mechanisms. A fundamental challenge for the field is to assemble our detailed knowledge of these specific mechanisms into a coherent picture of how plasticity within cortical circuits works to tune network properties.