Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor.
Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor.
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DOI：
10.1084/jem.177.1.119
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发表时间：
1993-01-01
期刊：
影响因子：
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通讯作者：
Kappler JW
中科院分区：
文献类型：
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作者：
White J;Pullen A;Choi K;Marrack P;Kappler JW
我们研究了鸽子细胞色素c（cyto c）特异性V β 3+/V α 11+ T细胞受体的V β部分突变对其识别cyto c/IEk和各种超抗原的能力的影响。结果与受体V β结构域的免疫球蛋白样结构一致，并且与常规抗原和超抗原的V β上的单独相互作用位点一致。预测位于CDR 1中的氨基酸对于cyto c/IEk识别是关键的，而不是超抗原识别，而预测位于高变区4环中的几个氨基酸对于超抗原识别是关键的，而不是cyto c/IEk识别。
We examined the effect of mutations in the V beta portion of a pigeon cytochrome c (cyto c)-specific V beta 3+/V alpha 11+ T cell receptor on its ability to recognize cyto c/IEk and various superantigens. The results were consistent with an immunoglobulin-like structure for the receptor V beta domain and with separate interaction sites on V beta for conventional antigen and superantigens. An amino acid predicted to lie in CDR1 was critical for cyto c/IEk but not superantigen recognition, while several amino acids predicted to lie in the hypervariable region 4 loop were critical for superantigen but not cyto c/IEk recognition.