Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival
Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival
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DOI：
10.1093/aje/kwn120
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发表时间：
2008-07-01
影响因子：
5
通讯作者：
Lawrence, Gill
中科院分区：
文献类型：
--
作者：
Duffy, Stephen W.;Nagtegaal, Iris D.;Lawrence, Gill
筛查发现的癌症患者的生存时间的确定受到时间和长度偏差的影响。作者提出了一种简单的提前时间修正方法，假定临床前筛查可检测的时间呈指数分布。假设两种潜在的肿瘤类别，其中一种更容易被筛查出来，相应地不太容易死于所讨论的癌症，作者开发了一种对不同程度的长度偏差进行敏感性分析的策略。在这里，他们使用了来自英国西米德兰兹郡的一系列25,962例乳腺癌病例(1988-2004年)来演示这些方法。
Determination of survival time among persons with screen-detected cancer is subject to lead time and length biases. The authors propose a simple correction for lead time, assuming an exponential distribution of the preclinical screen-detectable period. Assuming two latent categories of tumors, one of which is more prone to screen detection and correspondingly less prone to death from the cancer in question, the authors have developed a strategy of sensitivity analysis for various magnitudes of length bias. Here they demonstrate these methods using a series of 25,962 breast cancer cases (1988-2004) from the West Midlands, United Kingdom.