Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats
Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats
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DOI：
10.1097/00000374-200108000-00008
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发表时间：
2001-08-01
影响因子：
3.2
通讯作者：
Li, TK
中科院分区：
文献类型：
--
作者：
Rodd-Henricks, ZA;Bell, RL;Li, TK
工作背景：酒精剥夺效应（ADE）是指在一段时间的酒精剥夺后，自愿摄入乙醇溶液的暂时增加。多次剥夺可延长ADE的表达。本研究探讨了初始剥夺长度的影响，同时暴露于多种乙醇浓度，和剥夺暴露的数量上的ADE在酒精偏好（P）rates.Methods的幅度和持续时间：成年雌性P大鼠接受24小时自由选择访问10，20，和30%的乙醇和水6周。然后将大鼠随机分为三组;一组作为非剥夺对照组，而另外两组最初被剥夺乙醇2或8周。两个剥夺组均恢复乙醇溶液2周，然后再剥夺乙醇2周。这个周期重复三次，共四个deprivations.Results：在最初的乙醇剥夺期后，两个剥夺组表现出类似的2倍增加乙醇摄入量（克/公斤/天）在最初的24小时期间，当乙醇恢复。两个剥夺组在再次暴露后，20%和30%乙醇溶液的摄入量增加了2倍以上。在随后的剥夺期之前，乙醇消耗量在2周内恢复到基线水平。多次剥夺增加了ADE的幅度比在第一次剥夺中观察到的在最初的24小时期间的再曝光和延长的ADE的持续时间。此外，重复剥夺增加乙醇摄入量的第一个2小时期间的再曝光，并产生血液中的乙醇水平超过150毫克/100毫升。结论：酒精的强化和/或厌恶的影响发生改变后，一个单一的长期剥夺，并加强与重复剥夺。
Background: The alcohol deprivation effect (ADE) is a temporary increase in the voluntary intake of ethanol solutions following a period of alcohol deprivation. Multiple deprivations can prolong the expression of an ADE. This study examined the effects of initial deprivation length, concurrent exposure to multiple ethanol concentrations, and number of deprivation exposures on the magnitude and duration of the ADE in alcohol -preferring (P) rats.Methods: Adult female P rats received 24-hr free-choice access to 10, 20, and 30% ethanol and water for 6 weeks. Rats were then randomly assigned to three groups; one group served as a nondeprived control, whereas the other two groups were initially deprived of ethanol for 2 or 8 weeks. The ethanol solutions were restored to both deprived groups for 2 weeks before the groups were deprived of ethanol for another 2 weeks. This cycle was repeated three times for a total of four deprivations.Results: After the initial ethanol deprivation period, both deprived groups displayed a similar 2-fold increased ethanol intake (g/Kg/day) during the initial 24-hr period when ethanol was restored. Both deprived groups showed greater than 2-fold increases in intake of the 20 and 30% ethanol solutions after re-exposure. Ethanol consumption returned to baseline levels within 2 weeks, before the subsequent deprivation period. Multiple deprivations increased the magnitude of the ADE over that observed in the first deprivation during the initial 24-hr period of re-exposure and prolonged the duration of the ADE. In addition, repeated deprivations increased ethanol intake in the first 2-hr period of re-exposure and produced blood ethanol levels in excess of 150 mg/100 ml.Conclusions: Alterations in the reinforcing and/or aversive effects of alcohol occurred after a single prolonged deprivation and were enhanced with repeated deprivations.