A role for calcium in the acute and chronic actions of ethanol in vitro.
A role for calcium in the acute and chronic actions of ethanol in vitro.
复制标题
钙在乙醇体外急性和慢性作用中的作用。
DOI：
10.1016/0014-2999(80)90328-3
复制
发表时间：
1980
影响因子：
5
通讯作者：
H. Kalant
中科院分区：
文献类型：
--
作者：
J. Mayer;J. Khanna;H. Kalant
浓度为40-160 mM的乙醇以剂量依赖性方式抑制豚鼠回肠纵肌/肌间神经丛（LM/MP）制剂的电诱发收缩。提高细胞外钙离子浓度可部分逆转急性乙醇抑制作用。通过每日腹膜内注射进行4周的体内乙醇处理后，LM/MP制剂对乙醇耐受，同时钙在逆转乙醇的抑制作用方面更有效。看来钙在乙醇的急性乙醇作用和对乙醇耐受性的发展中起作用。
Ethanol, in a concentration of 40–160 mM, depressed the electrically evoked contractions of the guinea-pig ileum longitudinal muscle/myenteric plexus (LM/MP) preparation in a dose-dependent manner. The acute ethanol inhibition in vitro was partially reversed by raising the extracellular calcium concentration. Following a 4 week ethanol treatment in vivo, by means of daily i.p. injections, the LM/MP preparation was rendered tolerant to ethanol and at the same time calcium was more effective in reversing the inhibitory effect of ethanol. It appears that calcium plays a role in the acute ethanol action of, and development of tolerance to, ethanol.