Relation Between C-Reactive Protein, Homocysteine Levels, Fibrinogen, and Lipoprotein Levels and Leukocyte and Platelet Counts, and 10-Year Risk for Cardiovascular Disease Among Healthy Adults in the USA
Relation Between C-Reactive Protein, Homocysteine Levels, Fibrinogen, and Lipoprotein Levels and Leukocyte and Platelet Counts, and 10-Year Risk for Cardiovascular Disease Among Healthy Adults in the USA
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DOI：
10.1016/j.amjcard.2009.12.045
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发表时间：
2010-05-01
影响因子：
2.8
通讯作者：
Kim, Jae-Hyung
中科院分区：
文献类型：
--
作者：
Park, Chan Seok;Ihm, Sang-Hyun;Kim, Jae-Hyung
全身炎症与根据Fragrance风险评分估计的冠状动脉疾病（CAD）10年风险之间的关联在很大程度上是未知的。在这项研究中，6，371名参与第三次全国健康与营养检查调查的参与者（NHANES III），年龄40 - 79岁，无心脏病发作、中风、外周动脉疾病或糖尿病史，根据10年CAD风险分为低风险组（20%），使用由国家胆固醇教育计划成人治疗小组III修改的Fragrance风险评分计算。在对年龄、性别、种族、体重指数和合并症进行调整后，高风险参与者更有可能出现循环C反应蛋白水平升高（>= 2.2 mg/L：校正比值比[OR] 1.61，95%置信区间[CI] 1.30至2.01，p <0.0001;> 10.0 mg/L：OR 1.41，95% CI 1.03至1.93，p = 0.034）。高危组的循环纤维蛋白原、同型半胱氨酸、白细胞和血小板水平为20.98 mg/dl（95% CI 12.53至29.43，p <0.0001），1.54 μ mol/L（95% CI 0.76 - 2.32，p = 0.002），0.90 μ mol/L（95% CI 0.36 - 1.43，p = 0.001），910/μ l（95%CI 670~1，160，p <0.0001）和10，220/mu l（95%CI 2，830~17，610，p <0.0001）。在CAD风险类别中，炎症标志物的循环水平也呈剂量依赖性增加。总之，这些研究结果表明，低度全身炎症和高同型半胱氨酸血症存在于参与者与高10年风险的CAD。(C)2010年爱思唯尔公司All rights reserved. (Am J Cardiol 2010; 105：1284 - 1288）
The association between systemic inflammation and the estimated 10-year risk for coronary artery disease (CAD) according to the Framingham risk score is largely unknown. In this study, 6,371 participants in the Third National Health and Nutrition Examination Survey (NHANES III) aged 40 to 79 years, who had no histories of heart attack, stroke, peripheral artery disease, or diabetes mellitus, were categorized into groups at low (20%) risk according to 10-year risk for CAD, calculated using the Framingham risk score modified by the National Cholesterol Education Program Adult Treatment Panel III. After adjustments for age, gender, race, body mass index, and co-morbidities, participants at high risk were more likely to have elevated circulating C-reactive protein levels (>= 2.2 mg/L: adjusted odds ratio [OR] 1.61, 95% confidence interval [CI] 1.30 to 2.01, p < 0.0001; >10.0 mg/L: OR 1.41, 95% CI 1.03 to 1.93, p = 0.034). The high-risk group had circulating fibrinogen, homocysteine, leukocyte, and platelet levels that were 20.98 mg/dl (95% CI 12.53 to 29.43, p < 0.0001), 1.54 mu mol/L (95% CI 0.76 to 2.32, p = 0.002), 0.90 mu mol/L (95% CI 0.36 to 1.43, p = 0.001), 910/mu l (95% CI 670 to 1,160, p < 0.0001), and 10,220/mu l (95% CI 2,830 to 17,610, p < 0.0001) higher, respectively, than in those in the low-risk group. There was also a dose-dependent increase in circulating levels of inflammatory markers across the categories of CAD risk. In conclusion, these findings indicate that low-grade systemic inflammation and hyperhomocysteinemia were present in participants with high 10-year risk for CAD. (C) 2010 Elsevier Inc. All rights reserved. (Am J Cardiol 2010;105:1284-1288)