Reduced coronary artery and abdominal aortic calcification in Hispanics with type 2 diabetes
Reduced coronary artery and abdominal aortic calcification in Hispanics with type 2 diabetes
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DOI：
10.2337/diacare.27.5.1115
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发表时间：
2004-05-01
期刊：
影响因子：
16.2
通讯作者：
Sacks, J
中科院分区：
文献类型：
--
作者：
Reaven, PD;Sacks, J
目的：比较西班牙裔和非西班牙裔白人（NHW） 2型糖尿病患者的生活方式因素、心血管危险因素以及冠状动脉钙（CAC）和腹主动脉钙（AAC）水平。研究设计和方法：我们最近在一组非转诊、健康、非糖尿病受试者中证明，尽管心血管危险因素更差，但西班牙裔患者的CAC比非糖尿病患者低。在这项研究中，我们评估了这种血管钙化的种族差异是否存在于2型糖尿病患者和几种不同的动脉床中。通过问卷调查和血浆生物标志物测定，评估西班牙裔和非西班牙裔2型糖尿病患者（n = 245）的心血管危险因素。采用电子束计算机辅助断层扫描测量CAC和AAC。结果：尽管西班牙裔美国人比非裔美国人略年轻，但其他标准危险因素和新型心血管危险因素，包括纤溶酶原激活物-1和纤维蛋白原水平，在两组之间相似。尽管有相似的危险因素，但西班牙裔美国人心血管疾病（CVD）患病率以及CAC和AAC的平均和中位水平较低。此外，这些钙评分的分布与NHWs不同（P < 0.05），具有高CAC或AAC评分的西班牙裔受试者明显较少。这些差异不能用心血管疾病患病率或任何测量的生活方式或风险因素的差异来解释。结论：与NHW受试者相比，西班牙裔2型糖尿病患者的CAC和AAC水平降低，表明血管钙化和动脉粥样硬化的总体负担减轻。这些数据与拉美裔人不患心血管疾病的观点一致。
OBJECTIVE - To compare lifestyle factors, cardiovascular risk factors, and coronary artery calcium (CAC) and abdominal aortic calcium (AAC) levels in Hispanic and non-Hispanic White (NHW) individuals with type 2 diabetes.RESEARCH DESIGN AND METHODS - We recently demonstrated in a small group of nonreferred, healthy, nondiabetic Subjects that CAC was reduced in Hispanics compared with NHWs, despite a worse cardiovascular risk factor profile. In this Study, we evaluated whether this ethnic disparity in vascular calcification was present in individuals with type 2 diabetes and in several different arterial beds. Hispanic and NHW subjects (n = 245) with type 2 diabetes were evaluated for cardiovascular risk factors using questionnaires and assays of plasma biomarkers. CAC and AAC were measured by electron-beam computer-assisted tomography.RESULTS - Although Hispanics were slightly younger than NHWs, other standard risk factors and novel cardiovascular risk factors, including plasminogen activator-1 and fibrinogen levels, were similar between the groups. Despite the similar risk factor profile, the prevalence of cardiovascular disease (CVD) and mean and median levels of CAC and AAC were lower in Hispanics. Furthermore, the distribution Of these Calcium scores differed from that of NHWs (P < 0.05), with significantly fewer Hispanic :subjects having high CAC or AAC scores. These differences were not explained by differences in CVD prevalence or any measured lifestyle or risk factor.CONCLUSIONS - Hispanics with type 2 diabetes have reduced CAC and AAC levels compared With NHW subjects, suggesting a reduction in the overall burden of vascular calcification and atherosclerosis. These data are consistent with the notion that Hispanics are protected against the development of CVD.