Selective and total sleep deprivation: Effect on the sleep EEG in the rat
Selective and total sleep deprivation: Effect on the sleep EEG in the rat
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DOI：
10.1016/s0165-1781(96)03029-6
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发表时间：
1997-02-07
影响因子：
11.3
通讯作者：
Tobler, I
中科院分区：
文献类型：
--
作者：
Endo, T;Schwierin, B;Tobler, I
尽管已知睡眠剥夺对抑郁症患者具有抗抑郁作用，但睡眠调节的参与仍不清楚。在大鼠中进行选择性睡眠剥夺实验，以研究动物模型中非快速眼动睡眠 (NREMS) 和快速眼动睡眠 (REMS) 之间的相互作用。 A12 小时总睡眠剥夺 (TD) 期在开灯时结束，随后执行以下方案之一：(1) 恢复睡眠 (TD12)； (2) 4小时完全睡眠剥夺(TD16)； (3) 4小时慢波剥夺(SWD)； (4) 4 小时 REMS 剥夺 (RD)。在 SWD 协议中，EEG 慢波活动（SWA；0.75-4.0 Hz 频段的功率密度）的减少是通过将 NREMS 发作缩短至 20 秒来实现的。在 RD 期间，预防 REMS 所需的干预次数在前 2 小时内增加，然后保持不变。虽然 RD 仅导致 NREMS 的轻微减少，但它逐渐抑制了 NREMS 中的 SWA。 RD后SWA的反弹发生较晚，且不如SWD后明显。尽管在所有三个 4 小时睡眠剥夺方案后均出现 REMS 反弹，但仅在 TD16 后才出现黑暗期的持续增加。结论是 (a) NREMS 中的 SWA 受到 REMS 倾向水平增加的抑制； (b) 不支持 REMS 倾向仅在 NREMS 期间增加的假设； (c) 结果与以下假设相一致：NREMS 强度的抑制是抑郁症患者不同抗抑郁睡眠操作的共同点。 (C) 1997 爱思唯尔科学爱尔兰有限公司
Although sleep deprivation is known to exert an antidepressant effect in depressed patients, the involvement of sleep regulation is still unknown. Selective sleep deprivation experiments were performed in the rat to investigate the interactions between non-REM sleep (NREMS) and REM sleep (REMS) in an animal model. A12-h total sleep deprivation (TD) period ending at lights on was followed by one of the following protocols: (1) recovery sleep (TD12); (2) 4-h total sleep deprivation (TD16); (3) 4-h slow-wave deprivation (SWD); (4) 4-h REMS deprivation (RD). In the SWD protocol, the reduction of EEG slow-wave activity (SWA; power density in the 0.75-4.0 Hz band) was obtained by curtailing NREMS episodes to 20 s. During RD the number of interventions required to prevent REMS increased during the first 2 h and then remained constant. While RD caused only a minor reduction of NREMS, it increasingly suppressed SWA in NREMS. The rebound of SWA occurred later and was less prominent after RD than after SWD. Whereas an REMS rebound occurred after all three 4-h sleep deprivation protocols, a persistent increase in the dark period was present only after TD16. It is concluded that (a) SWA in NREMS is inhibited by an increased level of REMS propensity; (b) the hypothesis that REMS propensity increases only during NREMS is not supported; and (c) the results are compatible with the hypothesis that the suppression of NREMS intensity is the common denominator of different antidepressive sleep manipulations in depressive patients. (C) 1997 Elsevier Science Ireland Ltd.