Probiotics: Properties, Examples, and Specific Applications
Probiotics: Properties, Examples, and Specific Applications
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DOI：
10.1101/cshperspect.a010074
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发表时间：
2013-03-01
影响因子：
5.4
通讯作者：
Raffatellu, Manuela
中科院分区：
文献类型：
--
作者：
Behnsen, Judith;Deriu, Elisa;Raffatellu, Manuela
益生菌是微生物群的有益成分，由于它们赋予宿主的健康益处，已经使用了几个世纪。然而，直到最近，益生菌对免疫、呼吸和胃肠道功能调节的贡献才开始得到充分的认识和科学的评价。益生菌如大肠杆菌Nissle 1917和乳酸菌目前用于或已被评估用于预防或治疗一系列肠道疾病，包括炎症性肠病、便秘和结肠癌。将这些天然益生菌工程化以产生免疫调节分子可能有助于进一步增加对宿主的益处。在这篇文章中，我们将讨论益生菌的作用机制以及益生菌合理设计的进展。
Probiotics are beneficial components of the microbiota that have been used for centuries because of the health benefits they confer to the host. Only recently, however, has the contribution of probiotics to modulation of immunological, respiratory, and gastrointestinal functions started to be fully appreciated and scientifically evaluated. Probiotics such as Escherichia coli Nissle 1917 and lactic acid bacteria are currently used to, or have been evaluated for use to, prevent or treat a range of intestinal maladies including inflammatory bowel disease, constipation, and colon cancer. Engineering these natural probiotics to produce immunomodulatory molecules may help to further increase the benefit to the host. In this article, we will discuss some of the mechanisms of action of probiotics as well as advances in the rational design of probiotics.