Aging, energy expenditure and nutritional status: evidence for denutrition-related hypermetabolism.
Aging, energy expenditure and nutritional status: evidence for denutrition-related hypermetabolism.
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衰老、能量消耗和营养状况：营养不足相关代谢亢进的证据。
DOI：
10.1159/000177728
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发表时间：
1992
影响因子：
3.9
通讯作者：
P. Fouet
中科院分区：
文献类型：
--
作者：
B. Campillo;P. Bories;M. Devanlay;B. Pornin;J. L. Le Parco;E. Gaye;P. Fouet
本文对39例老年住院病人（平均年龄84.0 ± 6.9岁）的静息能量消耗（REE）和营养状况进行了评价。随着年龄的增长，营养状况下降，如年龄分别与体重（p < 0.001）、去脂肪质量（FFM）（p < 0.01）和体重指数（BMI）（p < 0.01）之间的显著负相关。当考虑整个群体时，FFM给出了REE的最佳预测（p < 0.001）。在近期手术后的患者中观察到与炎症状态相关的REE增加，如通过C反应蛋白和类粘蛋白的血浆水平增加所示。与炎症状态无关，REE也与营养状况有关：BMI 20的患者< 20 had higher REE than patients with a BMI >（28.4 +/- 1.3 vs. 22.1 +/- 0.7 kcal/kg体重; p < 0.001; 35.7 +/- 1.6 vs. 30.9 +/- 1.0 kcal/kg FFM; p < 0.02）。这些结果越来越多地表明，老年患者可能患有与高代谢相关的营养不良。
Resting energy expenditure (REE) and nutritional status have been evaluated in 39 elderly inpatients (mean age 84.0 +/- 6.9 years). The nutritional status declined with aging as shown by significant negative correlations between age and, respectively, weight (p < 0.001), fat free mass (FFM) (p < 0.01) and body mass index (BMI) (p < 0.01). The best prediction for REE when considering the whole population was given by FFM (p < 0.001). Increased REE was observed in patients after recent surgery, related to an inflammatory state, as shown by increased plasma levels of C-reactive protein and orosomucoid. Irrespectively of the inflammatory state, REE was also found to be related to the nutritional status: patients who showed a BMI < 20 had higher REE than patients with a BMI > 20 (28.4 +/- 1.3 vs. 22.1 +/- 0.7 kcal/kg of body weight; p < 0.001; 35.7 +/- 1.6 vs. 30.9 +/- 1.0 kcal/kg of FFM; p < 0.02). These results increasingly suggest that elderly patients may suffer from denutrition relevant to hypermetabolism.