Late reactivation of calcified granuloma in a patient with chronic suppurative brucellosis
Late reactivation of calcified granuloma in a patient with chronic suppurative brucellosis
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DOI：
10.1007/s10096-002-0848-4
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发表时间：
2002-12-01
影响因子：
4.5
通讯作者：
Morata, P
中科院分区：
文献类型：
--
作者：
Colmenero, JD;Suarez-Muñoz, MA;Morata, P
布鲁氏菌是世界上主要的人畜共患病病原体之一。它造成了巨大的经济损失以及流行地区相当大的人类发病率[1]。每年报告的人类布鲁氏菌病新发病例超过50万例。这种疾病在一些地中海国家流行，是一个重要的公共卫生问题。在人类中，布鲁氏菌病表现为具有非常异质性的临床谱的全身感染。该病通常表现为发热，无明显病灶，但20-40%的病例有局灶性并发症[2]。慢性肝脾脓肿（CHSA）是布鲁氏菌病的一种严重但罕见的并发症。对文献的检索只发现了60例病例。CHSA似乎是一种具有自身特征的临床实体，可与脾梗死伴脓肿（偶尔与心内膜炎相关）和布鲁氏菌病急性菌血症型中检出的小的无症状脓肿明确区分。关于CHSA的发病机制和最合适的治疗方法存在争议[3]。
Brucella is one of the world's major zoonotic pathogens. It is responsible for enormous economic losses as well as considerable human morbidity in endemic areas [1]. More than 500,000 new cases of human brucellosis are reported every year. The disease is endemic in some Mediterranean countries, where it represents an important public health problem. In humans, brucellosis behaves as a systemic infection with a very heterogeneous clinical spectrum. The disease usually presents as fever with no apparent focus, although in 20–40% of cases there are focal complications [2].Chronic hepatosplenic abscess (CHSA) is a severe, though infrequent, complication of brucellosis. A search of the literature revealed just 60 cases. CHSA appears to be a clinical entity with its own characteristics, which clearly differentiate it from splenic infarctions with abscesses, occasionally associated with endocarditis, and from small, asymptomatic abscesses detected in acute bacteremic forms of brucellosis. Controversy exists concerning the pathogenesis and most appropriate treatment of CHSA [3].