Characterization of a novel pyridinium bromide surface confined ionic liquid stationary phase for high-performance liquid chromatography under normal phase conditions via linear solvation energy relationships.
Characterization of a novel pyridinium bromide surface confined ionic liquid stationary phase for high-performance liquid chromatography under normal phase conditions via linear solvation energy relationships.
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DOI：
10.1016/j.chroma.2008.02.048
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发表时间：
2008-05
期刊：
影响因子：
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通讯作者：
D. S. Meter;O. D. Stuart;A. B. Carle;A. Stalcup
中科院分区：
文献类型：
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作者：
D. S. Meter;O. D. Stuart;A. B. Carle;A. Stalcup
利用线性溶剂化自由能关系方法，在正相液相色谱条件下表征了一种新型的溴化吡啶表面受限离子液体(SSEL)固定相。利用一组有限的中性芳香族探针溶液，使用异丙醇修饰的己烷流动相，快速评估LSER模型的实用性。在本研究中使用的流动相组成范围内的整体拟合度与实验值和计算值(R2=0.994)具有很好的相关性，表明LSER模型是描述正常相条件下这种极性键合相的合适模型。对于有限的化合物子集，在NP条件下，在溴化吡啶固定相上的保留与在氰基色谱柱上的保留比在二醇色谱柱上的保留更相关。
Utilizing linear solvation free energy relationship methodology, a novel pyridinium bromide surface confined ionic liquid (SCIL) stationary phase was characterized under normal phase high-performance liquid chromatographic conditions. A limited set of neutral aromatic probe solutes were utilized to rapidly assess the utility of the LSER model, using mobile phases of hexane modified with 2-propanol. The excellent correlation of the global fit across the mobile phase composition range used in this study for the experimental and calculated retention values (R2=0.994) indicates that the LSER model is an appropriate model of characterizing this polar bonded phase under normal phase conditions. For a limited subset of compounds, retention on the pyridinium bromide SCIL stationary phase is more highly correlated with that obtained on a cyano column than on a diol column under NP conditions.