EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent.
EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent.
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EGF和姜黄素共封装纳米粒子/水凝胶系统作为有效的皮肤再生剂
DOI：
10.2147/ijn.s104350
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发表时间：
2016
影响因子：
8
通讯作者：
Guo G
中科院分区：
文献类型：
--
作者：
Li X;Ye X;Qi J;Fan R;Gao X;Wu Y;Zhou L;Tong A;Guo G
伤口愈合是一个复杂的多因素过程，依赖于协调的信号分子才能成功。表皮生长因子（EGF）是一种刺激伤口修复的促有丝分裂多肽;然而，对其应用的精确控制对于减少副作用和实现所需的治疗益处是必要的。此外，在伤口愈合过程中广泛的氧化应激通常抑制损伤组织的修复。局部应用姜黄素（Cur）等抗氧化剂可以保护组织免受氧化损伤，并显着改善组织重塑。为了实现更快的伤口愈合效果，我们设计了一种新型的双重药物共载原位凝胶形成纳米颗粒/水凝胶系统（EGF-Cur-NP/H），其不仅作为再生组织的支持基质，而且作为EGF和Cur的持续药物储存库。在建立的切除全层伤口模型中，相对于生理盐水、纳米颗粒/水凝胶（NP/H）、Cur-NP/H和EGF-NP/H处理组，EGF-Cur-NP/H处理通过增加肉芽组织形成、胶原蛋白沉积和血管生成显著增强伤口闭合。总之，本研究提供了一种生物相容性原位凝胶形成系统，用于组织修复景观中EGF和Cur的有效局部应用。
Wound healing is a complex multifactorial process that relies on coordinated signaling molecules to succeed. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair; however, precise control over its application is necessary to reduce the side effects and achieve desired therapeutic benefits. Moreover, the extensive oxidative stress during the wound healing process generally inhibits repair of the injured tissues. Topical applications of antioxidants like curcumin (Cur) could protect tissues from oxidative damage and significantly improve tissue remodeling. To achieve much accelerated wound healing effects, we designed a novel dual drug co-loaded in situ gel-forming nanoparticle/hydrogel system (EGF-Cur-NP/H) which acted not only as a supportive matrix for the regenerative tissue, but also as a sustained drug depot for EGF and Cur. In the established excisional full-thickness wound model, EGF-Cur-NP/H treatment significantly enhanced wound closure through increasing granulation tissue formation, collagen deposition, and angiogenesis, relative to normal saline, nanoparticle/hydrogel (NP/H), Cur-NP/H, and EGF-NP/H treated groups. In conclusion, this study provides a biocompatible in situ gel-forming system for efficient topical application of EGF and Cur in the landscape of tissue repair.