Contrast enhanced high-resolution diffuse optical tomography of the human brain using ICG.
Contrast enhanced high-resolution diffuse optical tomography of the human brain using ICG.
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DOI：
10.1364/oe.19.018636
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发表时间：
2011-09-12
期刊：
影响因子：
3.8
通讯作者：
Steinbrink J
中科院分区：
文献类型：
--
作者：
Habermehl C;Schmitz CH;Steinbrink J
成人脑的非侵入性扩散光学断层扫描（DOT）最近已被证明可以提高功能性脑成像应用的空间分辨率。在这里，我们表明，高分辨率（HR）DOT也有利于使用光学造影剂的临床灌注成像。我们提出了第一个HR-DOT结果与连续波近红外光谱设置使用密集网格的光纤和吲哚菁绿色（ICG）作为外源造影剂。我们发现ICG团在脑内组织中的早期到达和团在脑外组织中的延迟到达，实现了两层的分离。这证明了该方法在神经重症监护患者脑灌注监测中的潜力。
Non-invasive diffuse optical tomography (DOT) of the adult brain has recently been shown to improve the spatial resolution for functional brain imaging applications. Here we show that high-resolution (HR) DOT is also advantageous for clinical perfusion imaging using an optical contrast agent. We present the first HR-DOT results with a continuous wave near infrared spectroscopy setup using a dense grid of optical fibers and indocyanine green (ICG) as an exogenic contrast agent. We find an early arrival of the ICG bolus in the intracerebral tissue and a delayed arrival of the bolus in the extracerebral tissue, achieving the separation of both layers. This demonstrates the method’s potential for brain perfusion monitoring in neurointensive care patients.