LIPOPROTEIN LIPID CONCENTRATIONS AND CARDIOVASCULAR RISK IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
LIPOPROTEIN LIPID CONCENTRATIONS AND CARDIOVASCULAR RISK IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
复制标题
DOI：
10.1210/jcem-61-5-946
复制
发表时间：
1985-01-01
影响因子：
5.8
通讯作者：
RANNEY, GB
中科院分区：
文献类型：
--
作者：
WILD, RA;PAINTER, PC;RANNEY, GB
29例多囊卵巢综合征（PCOS）患者与30例正常女性禁食12小时后进行脂蛋白脂质和雄激素的比较。多囊卵巢综合征和正常妇女在月经周期的增殖期进行评估。多囊卵巢综合征患者血清LH / FSH比值较高[2.0 .+-]。1.3 (.+-. sem) vs. 0.6 （+-. sem）0.1]，睾酮升高(T; 66。5 . vs. 33 .+-2 ng/ml)，较高的游离T(1.1 .+-。1 vs. 0.4。0.02 ng/dl)和更高的硫酸脱氢表雄酮(291 .+-。28 vs. 140。12 .mu。g/dl)水平和较低的t -雌激素结合球蛋白结合能力(1.5。0.2 vs. 2.2。0.1 .mu。g/dl)高于正常女性（均P < 0.05）。多囊卵巢综合征患者血清甘油三酯平均值较高[122 .+-]。11(+ -。Sem) 63 .+-。3毫克/分升]和非常低的密度脂蛋白胆固醇水平(24 .+-。2 . vs. 13 .+-1毫克/分升)，但较低的高密度脂蛋白胆固醇水平(43。58 .+-。2 mg / dl;P < 0.05)。虽然多囊卵巢综合征患者体重更重，久坐时间更长，饮食中饱和脂肪含量更高，纤维含量更低（P < 0.01），但脂蛋白脂质浓度的差异不能归因于体重。调整体重后，PCOS患者t -雌激素结合球蛋白结合能力与高密度脂蛋白胆固醇相关（r = 0.42; P = 0.025）。我们的结论是，女性高雄激素血症可能导致男性模式的脂蛋白脂质浓度。这些发现表明多囊卵巢综合征患者可能有增加的动脉粥样硬化的潜力。
Twenty-nine patients with polycystic ovary syndrome (PCOS) and 30 normal women had lipoprotein lipid and androgen profiles compared after a 12-h fast. Both PCOS and normal women were evaluated in the proliferative phase of the cycle. PCOS patients had higher serum LH to FSH ratios [2.0 .+-. 1.3 (.+-.SEM) vs. 0.6 .+-. 0.1], higher testosterone (T; 66 .+-. 5 vs. 33 .+-. 2 ng/ml), higher free T (1.1 .+-. 1 vs. 0.4 .+-. 0.02 ng/dl), and higher dehydroepiandrosterone sulfate (291 .+-. 28 vs. 140 .+-. 12 .mu.g/dl) levels, and lower T-estrogen-binding globulin-binding capacity (1.5 .+-. 0.2 vs. 2.2 .+-. 0.1 .mu.g/dl) than normal women (all P < 0.05). The PCOS patients had higher mean serum triglycerides [122 .+-. 11 (.+-. SEM) 63 .+-. 3 mg/dl] and very low density lipoprotein cholesterol levels (24 .+-. 2 vs. 13 .+-. 1 mg/dl), but lower high density lipoprotein cholesterol levels (43 .+-. 2 vs. 58 .+-. 2 mg/dl; P < 0.05). While PCOS patients were heavier and more sedentary and their diets were higher in saturated fat and lower in fiber (P < 0.01), respectively), the differences in lipoprotein lipid concentrations could not be attributed to body weight. T-estrogen-binding globulin-binding capacity correlated with high density lipoprotein cholesterol in PCOS patients (r = 0.42; P = 0.025) after adjusting for weight. We conclude that hyperandrogenemia in women may result in a male pattern of lipoprotein lipid concentrations. These findings suggest that PCOS patients may have increased atherogenic potential.