AIE luminogen bridged hollow hydroxyapatite nanocapsules for drug delivery
AIE luminogen bridged hollow hydroxyapatite nanocapsules for drug delivery
复制标题
用于药物输送的 AIE 发光体桥接中空羟基磷灰石纳米胶囊
DOI：
10.1039/c3dt50243k
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发表时间：
2013-01-01
影响因子：
4
通讯作者：
Xu, Ruren
中科院分区：
文献类型：
--
作者：
Li, Dongdong;Liang, Zhiqiang;Xu, Ruren
制备了一种基于四苯乙烯的新型有机膦酸——(4,4'-(1,2-二苯基乙烯-1,2-二基)双(4,1-亚苯基))双(亚甲基)二膦酸(PATPE)，其酯衍生物在DMSO-H2O溶液中表现出聚集诱导发射(AIE)的特性。然后通过一锅缩合工艺将 PATPE 制成羟基磷灰石，形成椭圆形形态的中空介孔纳米胶囊。 AIE发光体桥接的中空羟基磷灰石纳米胶囊在紫外线照射下发出强蓝光，进一步用于以布洛芬（IBU）为模型药物的药物输送。材料的荧光强度随着IBU的加载和释放而变化很大，表明可以通过发光强度的变化来跟踪药物的释放过程。还使用 MTT 测定在 HUH7 人肝癌细胞上评估了 AIE 发光体功能化材料的生物相容性。该材料的低细胞毒性表明所制备的多功能羟基磷灰石将成为潜在生物应用中同时药物输送和细胞成像的新候选者。
A new type of organophosphonic acid, (4,4'-(1,2-diphenylethene-1,2-diyl)bis(4,1-phenylene))bis(methylene)diphosphonic acid (PATPE), based on tetraphenylethene has been prepared, and its ester derivative exhibits the characteristic property of aggregation-induced emission (AIE) in DMSO-H2O solution. The PATPE is then fabricated into hydroxyapatite by a one-pot condensation process to form hollow mesoporous nanocapsules of ellipsoidal morphology. The AIE luminogen-bridged hollow hydroxyapatite nanocapsules emit strong blue light under UV irradiation, which is further used for drug delivery using ibuprofen (IBU) as a model drug. The fluorescence intensity of the materials varies greatly with the loading and release of IBU, suggesting that the drug release process may be tracked in terms of the change of luminescence intensity. The biocompatibility of AIE luminogen functionalized material is also evaluated on HUH7 human hepatoma cells using the MTT assay. The low cytotoxicity of the materials reveals that the as-prepared multifunctional hydroxyapatite will be a new candidate for simultaneous drug delivery and cell imaging in potential bioapplications.