Significant elevation of the levels of B-cell activating factor (BAFF) in patients with sarcoidosis
Significant elevation of the levels of B-cell activating factor (BAFF) in patients with sarcoidosis
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DOI：
10.1007/s10067-018-4183-2
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发表时间：
2018-10-01
影响因子：
3.4
通讯作者：
Kadota, Jun-ichi
中科院分区：
文献类型：
--
作者：
Ando, Masaru;Goto, Akihiko;Kadota, Jun-ichi
B细胞活化因子（BAFF）在B细胞的存活和分化以及抗体的产生中起重要作用。最近的研究表明，结节病患者血清BAFF水平升高;然而，他们没有研究这一发现与疾病临床特征的关系。本研究的目的是分析BAFF，并阐明BAFF水平与结节病的疾病活动性或严重程度之间的关系。88例结节病患者和21例健康志愿者参加了本研究。BAFF水平通过酶联免疫吸附试验测定。为了评估疾病的严重程度，我们检查了受累器官的数量、Schadding分期、呼吸功能损害（RFI）和Wasfi等人开发的评分系统。结节病患者的血清BAFF水平显著高于健康志愿者（中位数1553.0 vs 984.6 pg/ml，p < 0.001）。血清BAFF水平与疾病活动性指标呈正相关。血清和支气管肺泡灌洗液（BALF）中BAFF水平与疾病严重程度评分呈正相关（R = 0.367，p <0.001）。本研究表明，血清和BALF中的BAFF水平与疾病活动性标志物和疾病严重程度呈正相关。BAFF可作为疾病活动性和严重程度的指标。
B-cell activating factor (BAFF) plays an important role in the survival and differentiation of B-cells and production of antibodies. Recent studies show that the serum BAFF levels are elevated in patients with sarcoidosis; however, they have not studied the relationship of the finding with the clinical features of the disease. The purpose of the present study is to analyze the BAFF and to elucidate the relationship between BAFF levels and the disease activity or severity of sarcoidosis. Eighty-eight patients with sarcoidosis and 21 healthy volunteers were enrolled in the present study. The BAFF levels were measured by an enzyme-linked immunosorbent assay. To assess the disease severity, we examined the number of affected organs, Schadding stages, respiratory function impairment (RFI), and the scoring system developed by Wasfi et al. The serum BAFF levels in sarcoidosis patients were significantly higher than those in healthy volunteers (median 1553.0 vs 984.6 pg/ml, p < 0.001). There were positive correlations between the serum BAFF level and disease activity markers. In addition, there were positive correlations between the BAFF levels and the disease severity score in both the serum (R = 0.367, p < 0.001) and bronchoalveolar lavage fluid (BALF) (R = 0.376, p < 0.001). This study demonstrated that the BAFF levels in both the serum and BALF were positively correlated with the disease activity markers and disease severity. BAFF may be useful as an indicator of both the disease activity and severity.