EVOLUTIONARY CLUSTERING AND FUNCTIONAL SIMILARITY OF RNA-BINDING PROTEINS
EVOLUTIONARY CLUSTERING AND FUNCTIONAL SIMILARITY OF RNA-BINDING PROTEINS
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DOI：
10.1016/0014-5793(93)80749-k
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发表时间：
1993-12-06
期刊：
影响因子：
3.5
通讯作者：
GO, M
中科院分区：
文献类型：
--
作者：
FUKAMIKOBAYASHI, K;TOMODA, S;GO, M
参与剪接、加工和翻译调控的RNA结合蛋白(RNPs)含有一个到四个RNA结合域。我们构建了RNA结合域的系统发育树，包括聚(A)结合蛋白(PABP)、剪接因子、叶绿体RNPs、hnRNPs、SnRNP U1-70K、核仁素和果蝇性别决定因素。具有相似功能的蛋白质具有密切相关的RNA结合域和共同的结构域组织。根据这些观察结果，与其他RNP相比，人们可以根据其RNA结合结构域(S)与结构域组织之间的进化关系来假设其功能。
RNA-binding proteins (RNPs) involved in splicing, processing and translation regulation contain one to four RNA-binding domains. We constructed a phylogenetic tree for the RNA-binding domains, including those of poly(A)-binding protein (PABP), splicing factors, chloroplast RNPs, hnRNPs, snRNP U1-70K, nucleolin and Drosophila sex determinants. Proteins with similar functions were found to have closely related RNA-binding domains and common domain organizations. In light of these observation, one can assume the function of an RNA-binding protein, based on the evolutionary relationship between its RNA-binding domain(s) and domain organization, as compared with other RNPs.