Extracellular calcium sensed by a novel cation channel in hippocampal neurons.
Extracellular calcium sensed by a novel cation channel in hippocampal neurons.
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DOI：
10.1073/pnas.94.13.7012
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发表时间：
1997-06
影响因子：
11.1
通讯作者：
Zhi-gang Xiong;W.-Y. Lu;J. F. MacDonald
中科院分区：
文献类型：
--
作者：
Zhi-gang Xiong;W.-Y. Lu;J. F. MacDonald
Extracellular concentrations of Ca2+ change rapidly and transiently in the brain during excitatory synaptic activity. To test whether such changes in Ca2+ can play a signaling role we examined the effects of rapidly lowering Ca2+ on the excitability of acutely isolated CA1 and cultured hippocampal neurons. Reducing Ca2+ excited and depolarized neurons by activating a previously undescribed nonselective cation channel. This channel had a single-channel conductance of 36 pS, and its frequency of opening was inversely proportional to the concentration of Ca2+. The inhibition of gating of this channel was sensitive to ionic strength but independent of membrane potential. The ability of this channel to sense Ca2+ provides a novel mechanism whereby neurons can respond to alterations in the extracellular concentration of this key signaling ion.
