Cross-Coupling of Chloro(hetero)arenes with Thiolates Employing a Ni(0)-Precatalyst
Cross-Coupling of Chloro(hetero)arenes with Thiolates Employing a Ni(0)-Precatalyst
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DOI：
10.1021/acs.orglett.8b03476
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发表时间：
2019-01-04
期刊：
影响因子：
5.2
通讯作者：
Fleischer, Ivana
中科院分区：
文献类型：
--
作者：
Gehrtz, Paul H.;Geiger, Valentin;Fleischer, Ivana
描述了一种具有挑战性的芳基氯化物与原位生成的脂肪族和芳香族硫醇酸盐在镍催化下的一种普遍而有效的偶联反应。所采用的循环、空气稳定的镍预催化剂允许大范围的底物转化。在前所未有的适度催化剂负载和反应温度下，可以容忍各种官能团和杂环基元以及结构不同的硫醇。根据反应条件的不同，芳硫醇可以选择性地进行C-S或C-C偶联。
A general and efficient Ni-catalyzed coupling of challenging aryl chlorides and in situ generated aliphatic and aromatic thiolates is described. The employed on-cycle, air-stable defined Ni precatalysts allow for transformation of a broad scope of substrates. A variety of functional groups and heterocyclic motifs as well as structurally varied thiols are tolerated at unprecedented moderate catalyst loadings and reaction temperatures. Depending on reaction conditions, aryl thiols can selectively undergo C-S or C-C couplings.