Adolescent subgenual anterior cingulate activity is related to harm avoidance.
Adolescent subgenual anterior cingulate activity is related to harm avoidance.
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DOI：
10.1097/wnr.0b013e328317f3cb
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发表时间：
2009-01-07
期刊：
影响因子：
1.7
通讯作者：
Paulus MP
中科院分区：
文献类型：
--
作者：
Yang TT;Simmons AN;Matthews SC;Tapert SF;Frank GK;Bischoff-Grethe A;Lansing AE;Wu J;Paulus MP
最近的成人研究表明，膝下前扣带皮层（sgACC）参与基本的心理操作，如情感处理和抑制控制。然而，对青少年中抑制相关的sgACC功能知之甚少，也没有关于青少年中人格特征是否与抑制相关的sgACC大脑活动相关的公开数据。本研究探讨了人格与抑制相关的sgACC反应在健康青少年之间的关系。17名13-17岁的青少年进行功能性磁共振成像，同时执行参数停止信号任务。更高的伤害回避水平与抑制相关的sgACC活性增加显著相关。这些结果首次在青少年中建立了个性与差异性sgACC激活之间的联系。
Recent adult studies suggest that the subgenual anterior cingulate cortex (sgACC) is involved in fundamental mental operations such as affective processing and inhibitory control. However, little is known about inhibition-associated sgACC function in adolescents, and there are no published data regarding whether personality characteristics are related to inhibition-associated sgACC brain activity in adolescents. This study examined the relationship between personality and inhibition-associated sgACC response in healthy adolescents. Seventeen adolescents of 13–17 years of age underwent functional magnetic resonance imaging while performing a parametric stop-signal task. Greater harm avoidance levels were significantly associated with increased inhibition-related sgACC activity. These results establish, for the first time, a link between personality and differential sgACC activation in adolescents.