From estrogen to androgen receptor: A new pathway for sex hormones in prostate
From estrogen to androgen receptor: A new pathway for sex hormones in prostate
复制标题
DOI：
10.1073/pnas.95.10.5527
复制
发表时间：
1998-05-12
影响因子：
11.1
通讯作者：
Chang, CS
中科院分区：
文献类型：
--
作者：
Yeh, SY;Miyamoto, H;Chang, CS
虽然所有三种共激活剂 ARA(70)、类固醇受体共激活剂 1 和 RAC3/ACTR 都可以在 1 nM 二氢睾酮下增强雄激素受体 (AR) 转录活性，但我们在此证明，在 10 nM 17 β-雌二醇 (E2) 存在下，只有 ARA(70) 可以诱导 AR 转录活性 >30 倍，但己烯雌酚则不能。通过发现 E2-AR-ARA(70) 途径失败的 Reifenstein 部分雄激素不敏感综合征患者，进一步加强了这种新描述的 E2 诱导的 AR 转录活性在 DU145 人前列腺癌细胞中的重要性。总之，我们的数据首次表明，睾酮/二氢睾酮可能不是 AR 的唯一配体，E2 代表 AR 的另一种重要天然配体，可能对 AR 功能和男性生殖系统的发育发挥重要作用。
While all three coactivators ARA(70), steroid receptor coactivator 1, and RAC3/ACTR can enhance androgen receptor (AR) transcriptional activity at 1 nM dihydrotestosterone, we here demonstrate that only ARA(70) can induce AR transcriptional activity >30-fold in the presence of 10 nM 17 beta-estradiol (E2), but not diethylstilbestrol. The significance of this newly described E2-induced AR transcriptional activity in DU145 human prostate cancer cells was further strengthened by finding patients with Reifenstein partial-androgen insensitive syndrome that fail in the E2-AR-ARA(70) pathway. Together, our data suggest, for the first time, testosterone/dihydrotestosterone may not be the only ligands for the AR E2 represents another important natural ligand for AR that may play an essential role for the AR function and the development of the male reproductive system.