Arginase I and Polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro
Arginase I and Polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro
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DOI：
10.1016/s0896-6273(02)00826-7
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发表时间：
2002-08-15
期刊：
影响因子：
16.2
通讯作者：
Filbin, MT
中科院分区：
文献类型：
--
作者：
Cai, DM;Deng, KW;Filbin, MT
Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Either over-expression of Arginase I or exogenous polyamines can overcome inhibition by MAG and by myelin in general. While MAG/myelin support the growth of young DRG neurons, they become inhibitory as DRGs mature. Endogenous Arginase I levels are high in young DRGs but drop spontaneously at an age that coincides with the switch from promotion to inhibition by MAG/myelin. Over-expressing Arginase I in maturing DRGs blocks that switch. Arginase I and polyamines are more specific targets than cAMP for intervention to encourage regeneration after CNS injury.
