Animal models of female pelvic organ prolapse: lessons learned.
Animal models of female pelvic organ prolapse: lessons learned.
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DOI：
10.1586/eog.12.24
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发表时间：
2012-05-01
期刊：
影响因子：
--
通讯作者：
Damaser MS
中科院分区：
文献类型：
--
作者：
Couri BM;Lenis AT;Borazjani A;Paraiso MF;Damaser MS
盆腔器官脱垂是女性盆腔器官向阴道突出的现象。它在全世界范围内都很流行，给经济带来了巨大的负担。盆腔器官脱垂的病理生理学是多因素的，包括遗传倾向、异常结缔组织、肥胖、年龄增长、阴道分娩和其他危险因素。由于患者出现症状和人类研究的伦理问题之前需要很长时间，动物模型是必要且有用的。这些模型可以模仿不同的人类特征——组织学、解剖学或激素特征，但没有一个模型能同时呈现所有特征。主要动物模型包括基因敲除小鼠、大鼠、绵羊、兔子和非人灵长类动物。在本文中，我们讨论不同的动物模型及其在研究盆腔器官脱垂病理生理学自然进展和新治疗方法中的效用。
Pelvic organ prolapse is a vaginal protrusion of female pelvic organs. It has high prevalence worldwide and represents a great burden to the economy. The pathophysiology of pelvic organ prolapse is multifactorial and includes genetic predisposition, aberrant connective tissue, obesity, advancing age, vaginal delivery and other risk factors. Owing to the long course prior to patients becoming symptomatic and ethical questions surrounding human studies, animal models are necessary and useful. These models can mimic different human characteristics – histological, anatomical or hormonal, but none present all of the characteristics at the same time. Major animal models include knockout mice, rats, sheep, rabbits and nonhuman primates. In this article we discuss different animal models and their utility for investigating the natural progression of pelvic organ prolapse pathophysiology and novel treatment approaches.