Isocyanide-Based Multicomponent Bicyclization with Substituted Allenoate and Isatin: Synthesis of Unusual Spirooxindole Containing [5.5]-Fused Heterocycle
Isocyanide-Based Multicomponent Bicyclization with Substituted Allenoate and Isatin: Synthesis of Unusual Spirooxindole Containing [5.5]-Fused Heterocycle
复制标题
基于异氰化物的取代联烯酸酯和靛红的多组分双环化：合成含有[5.5]-稠合杂环的罕见螺吲哚
DOI：
10.1021/acs.joc.6b01711
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发表时间：
2016-10-07
影响因子：
3.6
通讯作者：
Li, Jian
中科院分区：
文献类型：
--
作者：
Tang, Zhongzhong;Liu, Zhiqiang;Li, Jian
公开了异氰酸酯、取代烯丙酸酯和isatin的三组分双环化反应。该方案通过Michael加成、双环化、[1,5]-氢化物移位顺序进行，形成2个新环和5个新化学键，包括C-C、C-O、C-N键。
A three-component bicyclization reaction of isocyanide, substituted allenoate, and isatin has been disclosed. This protocol is proposed to proceed through Michael addition, double cyclization, and [1,5]-hydride shift sequence, thus leading to the formation of two new rings and five new chemical bonds, including C-C, C-O, and C-N bonds.