Parental risk factors for fever in their children 7-10 days after the first dose of measles-containing vaccines.
Parental risk factors for fever in their children 7-10 days after the first dose of measles-containing vaccines.
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儿童在第一次接种麻疹疫苗后 7-10 天发烧的父母危险因素。
DOI：
10.1080/21645515.2019.1675458
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发表时间：
2020
影响因子：
4.8
通讯作者：
Klein,NicolaP
中科院分区：
文献类型：
--
作者：
Zerbo,Ousseny;Modaressi,Sharareh;Goddard,Kristin;Lewis,Edwin;Bok,Karin;Gans,Hayley;Klein,NicolaP
我们在一项队列研究中评估了父母的临床状况是否与儿童首次接种含麻疹疫苗（MCV）后的发热相关，该研究包括244，125名2009年至2016年出生于Kaiser Permanente北方加州的儿童，他们在1至2岁之间接受了MCV。在可能的情况下，每个孩子都与他/她的母亲和父亲联系在一起。父母的临床条件，目前之前和之后，他们的孩子的出生进行了鉴定。我们将儿童发热定义为在首次MCV给药后7-10天就诊于门诊和急诊科并伴有发热代码（“MCV相关发热”）。我们使用多变量逻辑回归分析评估了与MCV相关发热相关的父母临床状况。调整多个因素后，包括医疗保健利用、母亲发热[比值比（OR）= 1.19，95%置信区间（CI）1.06-1.32]、MCV后发热（OR = 5.90，95%CI 1.35-25.78），呼吸道感染（OR = 1.20，95% CI 1.10-1.31），偏头痛（OR = 1.14，95% CI 1.05-1.24），晕厥（OR = 1.14，95%CI 1.01-1.27）和原发性血小板增多症（OR = 1.93，95%CI 1.15-3.25）与MCV相关发热显著相关。父亲呼吸道感染（OR = 1.15，95%CI 1.05-1.27）、呼吸道感染相关发热（OR = 1.47，95%CI 1.23-1.76）和白癜风（OR = 1.63，95%CI 1.06-2.53）与MCV相关发热显著相关。父母的临床状况，特别是单纯发热和呼吸道感染相关发热，与MCV后7-10天的儿童发热相关。
We evaluated whether parental clinical conditions were associated with fever after a first dose of measles-containing vaccine (MCV) in the child in a cohort study including 244,125 children born in Kaiser Permanente Northern California between 2009 and 2016 who received MCV between ages 1 and 2 years. Each child was linked with his/her mother and father when possible. Parental clinical conditions present before and after their child’s birth were identified. We defined fever in the children as clinic and emergency department visits with a fever code 7–10 days after a first dose of MCV (“MCV-associated fever”). We evaluated parental clinical conditions associated with MCV-associated fever using multivariate logistic regression analyses. After adjusting for multiple factors, including healthcare utilization, maternal fever [odds ratio (OR) = 1.19, 95% confidence interval (CI) 1.06–1.32], fever after MCV (OR = 5.90, 95% CI 1.35–25.78), respiratory infections (OR = 1.20, 95% CI 1.10–1.31), migraine (OR = 1.14, 95% CI 1.05–1.24), syncope (OR 1.14, 95% CI 1.01–1.27), and essential thrombocythemia (OR = 1.93, 95% CI 1.15–3.25) were significantly associated with MCV-associated fever. Paternal respiratory infections (OR = 1.15, 95% CI 1.05–1.27), fever associated with respiratory infections (OR = 1.47, 95% CI 1.23–1.76), and vitiligo (OR = 1.63, 95% CI 1.06–2.53) were significantly associated with MCV-associated fever. Parental clinical conditions, specifically fever alone and fever associated with respiratory infection, are associated with fever in their child 7–10 days after MCV.