Heritabilities of Intraocular Pressure in the Population of Korea The Korean National Health and Nutrition Examination Survey 2008-2009
Heritabilities of Intraocular Pressure in the Population of Korea The Korean National Health and Nutrition Examination Survey 2008-2009
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DOI：
10.1001/jamaophthalmol.2013.7612
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发表时间：
2014-03-01
影响因子：
8.1
通讯作者：
Kim, Chan Yun
中科院分区：
文献类型：
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作者：
Kim, Na Rae;Park, Hyun Ju;Kim, Chan Yun
重要性眼内压（IOP）是原发性开角型青光眼进展的主要可变危险因素。在大量的匹配的父母-后代对直接测量IOP的研究是有限的，在亚洲population.Objective比较IOP的父母和他们的后代在Korea.DESIGN，SETTING，和PARTICIPANTS家庭为基础的队列研究，检查数据从韩国国家健康和营养检查调查2008年和2009年之间进行。从9700名来自韩国的参与者中获得数据。主要结果和测量在不同类型的亲属对中计算IOP的家族相关性。方差分量法用于获得遗传力估计。根据整个研究人群的平均值加2 SD IOP值，将个体分为2组（IOP>= 19 mm Hg的患者和IOP不>= 19 mm Hg的患者;即高IOP组和非高IOP组）。我们评估了父母的高眼压对后代的高眼压的影响。结果：患眼右眼和左眼的平均眼压分别为13.90（2.74）mm Hg和13.89（2.74）mm Hg;父母-子女对、兄弟姐妹对和配偶对之间IOP的相关系数估计值分别为0.19、0.31和0.29（分别为P <0.001、P = 0.001和P <0.001）。研究表型的总变异由2个变异来源解释，即加性遗传（36%[95% CI，32%-40%]）和独特环境（64%[95% CI，60%-68%]）。父母的高IOP所带来的高IOP风险对于父母有高IOP的参与者来说是显著的（比值比，9.76 [95%CI，2.16 - 44.12]）。在这项研究中，高眼压与父母的糖尿病，高血压，肥胖，或代谢syndrome. CONCLUSIONS AND RELEVANCE眼内压显示出显着的遗传倾向，从父母到他们的后代，在亚洲人群中的遗传度估计为0.36。父母患有高眼压的参与者患高眼压的风险显著增加。这对高眼压和青光眼患者家庭成员的筛查具有潜在的意义。
IMPORTANCE Intraocular pressure (IOP) is the principal modifiable risk factor for the progression of primary open-angle glaucoma. Studies that have measured the IOP directly in large numbers of matched parent-offspring pairs are limited in Asian populations.OBJECTIVE To compare IOPs in parents and their offspring in Korea.DESIGN, SETTING, AND PARTICIPANTS Family-based cohort study examining data from the Korean National Health and Nutrition Examination Survey conducted between 2008 and 2009. Data were obtained from 9700 participants from Korea.MAIN OUTCOMES AND MEASURES Familial correlations for IOP were calculated in different types of relative pairs. Variance component methods were used to obtain heritability estimates. The individuals were stratified into 2 groups (those with and those without an IOP of >= 19 mm Hg; ie, high IOP group and nonhigh IOP group) based on the mean plus 2 SD IOP value of the entire study population. We evaluated the impact of parents' high IOP on offspring's high IOP. The relationship between parental systemic disease and high IOP in their offspring was also investigated.RESULTS The mean (SD) IOPs in the right and left eyes were 13.90 (2.74) and 13.89 (2.74) mm Hg, respectively. Correlation coefficient estimates between parent-offspring pairs, sibling pairs, and spouse pairs for IOP were significant as 0.19, 0.31, and 0.29 (P < .001, P = .001, and P < .001, respectively). The total variance of the phenotype under study was explained by 2 sources of variation, additive genetic (36% [95% CI, 32%-40%]) and unique environment (64% [95% CI, 60%-68%]). The risks of high IOP conferred by parents' high IOP were found to be significant for participants whose parents had high IOP (odds ratio, 9.76 [95% CI, 2.16-44.12]). In this study, high IOP was not associated with parental diabetes mellitus, hypertension, obesity, or metabolic syndrome.CONCLUSIONS AND RELEVANCE Intraocular pressure showed a significant heritable tendency from parents to their offspring with a heritability estimate of 0.36 in Asian populations. The risk of high IOP was significantly increased in participants whose parents had high IOP. This has potential implications for the screening of family members of patients with ocular hypertension and glaucoma.