Morphology of mitochondria during apoptosis: worms-to-beetles in worms.
Morphology of mitochondria during apoptosis: worms-to-beetles in worms.
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DOI：
10.1016/j.devcel.2005.02.003
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发表时间：
2005-03
影响因子：
11.8
通讯作者：
R. Youle
中科院分区：
文献类型：
--
作者：
R. Youle
虽然线粒体对哺乳动物细胞凋亡的大多数途径至关重要，但令人沮丧的是，它们在经典的无脊椎动物程序性细胞死亡模型中的作用的证据很少。新的研究表明，在C. elegansdevelopment inhibits programmed cell death填补了这一空白，并将促进对线粒体在半胱天冬酶激活中作用的更详细理解。
Although mitochondria are crucial for most pathways of mammalian cell apoptosis, evidence for their role in classic invertebrate models of programmed cell death has been frustratingly scant. New work showing that inhibition of mitochondrial fragmentation duringC. elegansdevelopment inhibits programmed cell death bridges this gap and should advance a more detailed understanding of the role of mitochondria in caspase activation.